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Association of CCR5-Δ32 polymorphism with HBV infection in special population of Guizhou Province
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 22
- DOI:
- 10.3969/j.issn.1009-3079.2009.22.016
- Key Word:
- 趋化性细胞因子受体;多态性;世居少数民族;乙型肝炎病毒;感染
Abstract： 目的: 探讨CCR5Δ32等位基因在贵州世居少数民族(彝、瑶)与汉族人群的分布, 并分析CCR5位点突变与HBV的关系.方法: 采用PCR技术分别扩增贵州92份黔西彝族、101份威宁彝族、138份荔波瑶族以及165份毕节汉族CCR5编码区片段, 通过琼脂糖凝胶电泳对CCR5Δ32多态性进行分析, 最后抽取样本并进行DNA测序验证.结果: 经过PCR特异性扩增, 琼脂糖凝胶电泳后, 496份样本均未发现CCR5Δ32突变型和杂合子. DNA测序验证所有样本CCR5基因未发生32碱基缺失的突变.结论: CCR5Δ32的分布有较明显的地域和种族差异, 该位点与HBV感染的相关性有待于进一步深入研究.
- [1]冯涛,倪安平,杨国翠.CCR5基因32个碱基缺失突变的分子流行病学调查[J].2003,(2).
- [2]盛磊,常生军,程江.CCR5基因多态性的研究进展[J].2007,(4).
- [3]石宏,郝大林,孙成学.CCR5阳性细胞CD30阳性细胞检测在乙型肝炎中的临床应用[J].2007,(8).
- [4]徐维国,杨丽,刘小菁,等.CC族趋化因子受体基因多态性在乙型肝炎肝硬化中的作用[J].2009,(3).
- [5]蒲春文,姜春萌,丛树荣,等.细胞趋化因子受体CXCR3及CCR5在乙型肝炎患者肝组织中的表达[J].2005,(9).
- [6]陈森洲,陈哲,樊晓晖,等.广西罗城仫佬族人群HIV-1感染相关基因CCR5多态性的初步研究[J].2007,(6).
- [7]洪卫国,王福生,金磊,等.趋化因子CCR5、CCR2和SDF1基因多态性与HBV感染相关性初步研究[J].2003,(1).
- [8]J J, Martinson,N H, Chapman,D C, Rees,etc.Global distribution of the CCR5 gene 32-basepair deletion.[J].1997,16.
- [9]Fathi,Shahbazi M,Ebadi H.CCR5-delta 32 allele is associated with the risk of developing multiple sclerosis in the Iranian population.[J].2009,29(8).
- [10]Shin JS,Kim JK,Ahn SH,etc.Association of genetic variations in CCR5 and its ligand, RANTES with clearance of hepatitis B virus in Korea.[J].2006,78(12).
- [11]Yang Y,Swain MG,Aspinall AI,etc.Lack of Chemokine Receptor CCR5 Promotes Murine Fulminant Liver Failure by Preventing the Apoptosis of Activated CD1d-Restricted NKT Cells.[J].2005,174(12).
- [12]M, Samson,F, Libert,B J, Doranz,etc.Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.[J].1996,382.