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Expression of Survivin, COX-2 and VEGF in colorectal cancer and its correlation with tumor angiogenesis
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 20
- DOI:
- 10.3969/j.issn.1009-3079.2009.20.007
- Key Word:
- Survivin;环氧合酶-2;血管内皮生长因子;CD34;大肠癌
Abstract： 目的:研究Survivin, COX-2, VEGF和肿瘤微血管密度(MVD)在大肠癌组织中的表达, 探讨其与大肠癌肿瘤血管生成的关系.方法:2007-09/2008-05哈尔滨医科大学附属第二临床医学院内镜下取材的大肠癌、肠息肉及肠炎标本. 所有标本均经病理检查证实诊断. 试验对象共分3组, 分别为大肠癌组织26例, 大肠息肉组织10例, 大肠黏膜慢性炎症组织7例. 采用免疫组织化学方法检测Survivin,COX-2, VEGF和CD34在大肠组织中的表达.结果:Survivin, COX-2与VEGF蛋白在大肠癌组织中阳性表达率分别为76.9%, 80.8%和69.28%, 明显高于大肠息肉组与肠炎组的表达( P<0.01或0.05). 大肠癌组织中MVD(CD34)明显高于大肠息肉组与肠炎组(23.69±9.96 vs13.10±7.05, 10.43±4.24, 均P<0.01). Survivin,COX-2和VEGF蛋白在大肠癌组中的表达与MVD相关(均P<0.05), Survivin和促血管形成因子COX-2, VEGF在大肠癌组织中的表达密切相关(χ2 = 11.18, 4.72, 均P<0.005).结论:Survivin可能通过COX-2, VEGF促进大肠癌肿瘤血管的形成.
- [1]J, Folkman.Tumor angiogenesis: therapeutic implications.[J].1971,285(21).
- [2]Grapsa D,Athanassiades P,Athanassiadou P,etc.The prognostic significance of COX-2 and survivin expression in ovarian cancer.[J].2008,204(4).
- [3]Kausch I,Toma M,Kraemer K,etc.Antisense-mediated inhibition of survivin, hTERT and VEGF in bladder cancer cells in vitro and in vivo.[J].2008,32(5).
- [4]Yu-Hong, Li,Chun-Fang, Hu,Qiong, Shao,etc.Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma.[J].2008,6.
- [5]Altieri DC.Survivin, cancer networks and pathway-directed drug discovery.[J].2008,8(1).
- [6]Simosa HF,Conte MS,Wang GJ,etc.Regulation of vascular smooth muscle cell growth by survivin.[J].2007,15(6).
- [7]N, Weidner,G, Gasparini.Determination of epidermal growth factor receptor provides additional prognostic information to measuring tumor angiogenesis in breast carcinoma patients.[J].1994,29(1).
- [8]Iyengar M,Dai W,Beierle EA,etc.VEGF-mediated survivin expression in neuroblastoma cells.[J].2005,127(1).
- [9]Yong-Keun Jung,Byung-Je Sung,Jong-Ik Hwang,etc.An Anti-apoptotic Protein human Survivin Is a Direct Inhibitor of Caspase-3 and -7[J].2001,40(4).
- [10]J, Holash,P C, Maisonpierre,D, Compton,etc.Vessel cooption, regression, and growth in tumors mediated by angiopoietins and VEGF.[J].1999,284.
- [11]Gabriella, Calviello,Federica, Resci,Simona, Serini,etc.Docosahexaenoic acid induces proteasome-dependent degradation of beta-catenin, down-regulation of survivin and apoptosis in human colorectal cancer cells not expressing COX-2.[J].2007,28(6).
- [12]M, Mesri,M, Morales-Ruiz,E J, Ackermann,etc.Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting.[J].2001,158(5).
- [13]Duffy MJ,Untch M,Wang HJ,etc.Survivin expression in breast cancer predicts clinical outcome and is associated with HER2, VEGF, urokinase plasminogen activator and PAI-1.[J].2006,17(4).
- [14]Antonella, Cusimano,Daniela, Foderà,Natale, D'Alessandro,etc.Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway.[J].2007,6(9).
- [15]Hofman FM,Kardosh A,Pyrko P,etc.Reduced survivin expression and tumor cell survival during chronic hypoxia and further cytotoxic enhancement by the cyclooxygenase-2 inhibitor celecoxib.[J].2007,14(5).
- [16]Mori F,Piro FR,Mesiti G,etc.Survivin and Cyclooxygenase-2 are co-expressed in human and mouse colon carcinoma and in terminally differentiated colonocytes.[J].2007,22(1).
- [17]Schachtschneider P,Stoeltzing O,Mori A,etc.Dual targeting of Raf and VEGF receptor 2 reduces growth and metastasis of pancreatic cancer through direct effects on tumor cells, endothelial cells, and pericytes.[J].2008,7(11).
- [18]Flint P,Knox WF,Barnes N,etc.Survivin expression in in situ and invasive breast cancer relates to COX-2 expression and DCIS recurrence.[J].2006,94(2).
- [19]Jennifer Tran,Janusz Rak,Capucine Sheehan,etc.Marked Induction of the IAP Family Antiapoptotic Proteins Survivin and XIAP by VEGF in Vascular Endothelial Cells[J].1999,264(3).
- [20]R S, Houlston.What we could do now: molecular pathology of colorectal cancer.[J].2001,54(4).