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Advances in research on relationship between galectin-3 and liver diseases

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 19

DOI:: 10.3969/j.issn.1009-3079.2009.19.001

Key Word:: 半乳凝素3;肝脏疾病;脂肪肝;肝癌

Abstract：半乳凝素3(galectin 3, Gal-3)是一种相对分子质量为29-35 kDa的基因产物, 包含已报道的14种成员的糖结合蛋白家族的一员, 主要存在于细胞质中, 也可易位到核膜, 细胞核并且分泌到细胞外基质中. Gal-3参与细胞生长、增殖、分化、黏附, 炎症和免疫应答, 血管发生、凋亡以及肿瘤的进展和转移, 并且是糖基化终产物受体之一. 近年来人们开始关注Gal-3与各种肝脏疾病之间的关系, 如脂肪肝、肝纤维化、肝硬化和肝癌. 本文就此作一综述.

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