Abstract: As a new anti-platelet medicine, it has been more than 10 years since clopidogrel was applied to treat cardiovascular and cerebrovascular diseases. Recently, the increasing incidence and mortality of cardiovascular events in preventing clopidogrel associated gastrointestinal damage with PPI have been attracting wide attention of clinicians. This article reviews the present clinical application of clopidogrel, clopidogrel-induced gastrointestinal damage and its prevention strategy.