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Value of insulin-like growth factor binding protein 2 in early diagnosis of nonalcoholic fatty liver disease

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
16
DOI:
10.3969/j.issn.1009-3079.2009.16.014
Key Word:
非酒精性脂肪肝;胰岛素样生长因子结合蛋白2;酶联免疫吸附试验

Abstract´╝Ü 目的: 探讨血清胰岛素样生长因子结合蛋白2(insulin-like growth factor binding protein2, IGF B P2)定量检测对非酒精性脂肪肝(nonalcoholic fatty liver disease, NAFLD)的诊断价值.方法: 采用ELISA定量检测非酒精性脂肪肝患者与慢性肝炎、肝硬化、原发性肝癌以及健康成人血清中IGFBP2水平, 并进行统计学分析.结果: 轻度和中重度脂肪肝组患者血清中IGFBP2水平显著高于健康成人组、慢性肝炎组、肝硬化与原发性肝癌组水平(6.89±2.37μg/L, 4.86±1.97 μg/L vs 1.77±1.56 μg/L, 1.67±1.36 μg/L, 1.76±1.52 μg/L, 1.52±1.43 μg/L,均P<0.05), 且轻度脂肪肝组显著高于中重度脂肪肝组( P<0.05).结论: 监测IGFBP2水平有助于早期诊断非酒精性脂肪肝及了解病变严重程度.

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