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Expression of Bim gene in colorectal cancer
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 36
- DOI:
- 10.3969/j.issn.1009-3079.2008.36.007
- Key Word:
- 大肠肿瘤;Bim基因;预后
Abstract： 目的:探讨大肠癌组织中Bim基因的表达及其与大肠癌生物学特征和预后的关系.方法:收集哈尔滨医科大学附属肿瘤医院2001-2002年手术切除且资料完整的大肠癌组织标本98例,均经根治性手术治疗和病理确诊.同时取癌组织及癌旁5 cm处正常肠组织.采用免疫组化SP法检测Bim蛋白大肠癌及正常大肠组织中的表达.结果:Bim的阳性表达率在大肠癌组织中明显低于癌旁组织,差异有统计学意义(28.57%vs98.97%,P＜0.05).Bim蛋白表达下降或完全丧失与大肠癌的浸润深度、淋巴结转移及临床分期有关(X2=6.959,35.38 1,4.905,均P＜0.05),而与患者的年龄、肿瘤大小、组织学类型、分化程度无关.Bim表达阳性患者的生存率高于表达阴性患者的生存率(P＜0.05).Bim阳性表达者,术后平均生存时间比Bim表达阴性者长1.03 mo.结论:Bim在大肠癌的发生发展中起重要作用,对评价患者的预后有一定价值.
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