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Effects of botulinum toxin-A on gastric emptying,plasma motilin and serum leptin in rats
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 16
- DOI:
- 10.3969/j.issn.1009-3079.2008.16.017
- Key Word:
- A型肉毒毒素;胃排空;胃动素;瘦素
Abstract： 目的: 探讨A型肉毒毒素(botulinum A,BTA)对大鼠胃排空及某些激素的影响.方法:选用♂Wistar大鼠40只,随机分为4组:对照组、BTA小剂量(10U)组、中剂量(20U)组及大剂量(40U)组.给药方法均为剖腹胃窦部肌层注射.观察12wk,记录进食量及体质量变化.12wk末,测定胃半排空时间,放免法测定血浆胃动素和血清瘦素含量.结果:12wk与对照组相比,中、高剂量组大鼠进食量及体质量明显降低(24.25±1.33g,25.02±1.81g vs 30.61±2.07g;441.54±14.64g,437.33±20.73g vs 517.98±24.11g ,均P<0.05),胃半排时间显著延长(161.67±23.53min, 200.33±44.37min vs 86.83±22.98min, P<0.05),血浆胃动素含量减少,差别有统计学意义(80.56±10.43ng/L, 65.99±10.50ng/L vs 123.65±31.10ng/L, P<0.05);小、中、大剂量组血清瘦素均显著低于对照组(0.99±0.13μg/L,0.97±0.18μg/L,0.83±0.23μg/L vs 1.28±0.25μg/L),差别有统计学意义 P<0.05).结论:大鼠注射BTA后体内胃动素、瘦素含量减少,其可能影响体内某些激素的分泌.
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