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A randomized controlled study of 5-and 7-d pantoprazole quadruple regimens for Helicobacter pylori eradication

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 30

DOI:: 10.3969/j.issn.1009-3079.2007.30.018

Key Word:: 幽门螺杆菌;四联疗法;泮妥拉唑

Abstract：目的:比较泮妥拉唑四联5d疗法和7d疗法的Hpylori根除率和症状缓解率.方法:Hpylori阳性的胃炎、胃溃疡或十二指肠患者70例随机接受5d(34例)或7d(36例)泮妥拉唑四联疗法:泮妥拉唑40mg、克拉霉素250mg、阿莫西林1.0g和胶体枸橼酸铋钾220mg,均为2次/d.根除治疗后第4周复查Hpylori是否根除,了解症状缓解情况.结果:5d组Hpylori根除率为84.8%(PP)和82.4%(ITT),7d组Hpylori根除率为88.2%(PP)和83.3%(ITT),5d组疼痛缓解率为72.0%(PP)和69.2%(ITT),7d组疼痛缓解率为83.9%(ITT)和89.7%(PP).按PP及ITT组群分析,两组方案Hpylori根除率及疼痛缓解率无明显差异,两组患者均未出现严重不良反应.结论:泮妥拉唑四联5d疗法可以获得较高的Hpylori根除率和疼痛缓解率,可以作为Hpylori根除治疗的一线治疗方案.

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