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Effect of transforming growth factor-β3 on hepatic and pancreatic fibrosis

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
28
DOI:
10.3969/j.issn.1009-3079.2007.28.010
Key Word:
转化生长因子-β3;肝纤维化;胰腺纤维化

Abstract´╝Ü 组织纤维化的基本特征是细胞外基质降解减少、过度沉积,导致组织结构的改建.TGF-β3通过抑制胶原的沉积,促进其降解而具有抗纤维化作用,并被证实在创伤愈合过程中可减轻伤后疤痕的形成.本文着重介绍了TGF-β3在肝脏及胰腺纤维化中的表达及其作用,以进一步了解其对纤维化疾病的影响.

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