Paper - WANFANG MED ONLINE

You Position: Home > Paper

Effect of transforming growth factor-β3 on hepatic and pancreatic fibrosis

( views:178, downloads:8 )

Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 28

DOI:: 10.3969/j.issn.1009-3079.2007.28.010

Key Word:: 转化生长因子-β3;肝纤维化;胰腺纤维化

Abstract：组织纤维化的基本特征是细胞外基质降解减少、过度沉积,导致组织结构的改建.TGF-β3通过抑制胶原的沉积,促进其降解而具有抗纤维化作用,并被证实在创伤愈合过程中可减轻伤后疤痕的形成.本文着重介绍了TGF-β3在肝脏及胰腺纤维化中的表达及其作用,以进一步了解其对纤维化疾病的影响.

Reference

[1]孙蕴伟,袁耀宗.结缔组织生长因子及其在胰腺纤维化中的作用机制[J].2003,(2).
[2]Mahato RI,Cheng K.Gene modulation for treating liver fibrosis.[J].2007,24(2).
[3]Wai-Yee, Li,Eunice Y, Huang,Marek, Dudas,etc.Transforming growth factor-beta3 affects plasminogen activator inhibitor-1 expression in fetal mice and modulates fibroblast-mediated collagen gel contraction.[J].1900,14.
[4]Bochaton-Piallat ML,Phan SH,Galli A,etc.The myofibroblast: one function, multiple origins.[J].2007,170(6).
[5]Leonel, García B,Javier, Gálvez G,Juan, Armendáriz B.[Therapeutical targets for revert liver fibrosis].[J].2007,135(6).
[6]Yin JQ,Liu X,Hu H.Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis.[J].2006,26(1).
[7]Neiman J,Mulder KM,Liu G,etc.Requirement of Smad3 and CREB-1 in mediating transforming growth factor-beta (TGFbeta) induction of TGFbeta3 secretion.[J].2006,281(40).
[8]Huang JS,Huang SS.TGF-beta control of cell proliferation.[J].2005,96(3).
[9]Massague J..TGF-beta signal transduction [Review][J].1998,67.
[10]Kim SH,Suh CO,Chung EJ,etc.Early alteration in TGF-beta mRNA expression in irradiated rat liver.[J].2000,46(3).
[11]Parsons CJ,Takashima M,Rippe RA.Molecular mechanisms of hepatic fibrogenesis.[J].2007,22(Suppl.1).
[12]R, Urtasun,N, Nieto.[Hepatic stellate cells and oxidative stress].[J].2007,99(4).
[13]H, Friess,Z, Lu,E, Riesle,etc.Enhanced expression of TGF-betas and their receptors in human acute pancreatitis.[J].1998,227.
[14]H U, Baer,H, Friess,M, Abou-Shady,etc.Transforming growth factor betas and their receptors in human liver cirrhosis.[J].1998,10.
[15]Colombo F,Calderone A,Abdelaziz N,etc.Nitric oxide attenuates the expression of transforming growth factor-beta(3) mRNA in rat cardiac fibroblasts via destabilization.[J].2001,38(2).
[16]Wynn TA.Common and unique mechanisms regulate fibrosis in various fibroproliferative diseases.[J].2007,117(3).
[17]Ferguson MWJ,O'Kane S.Scar-free healing: from embryonic mechanisms to adult therapeutic intervention[J].2004,359(1445).
[18]Lim H,Zhu YZ.Role of transforming growth factor-beta in the progression of heart failure[J].2006,63(22).
[19]Spielmann P,Zimmermann R,Wenger RH,etc.Oxygen-regulated expression of TGF-beta 3, a growth factor involved in trophoblast differentiation.[J].2003,24(10).
[20]Ikegami T,Zhang Y,Matsuzaki Y.Liver fibrosis: possible involvement of EMT.[J].2007,185(1/3).
[21]Crowe DL,Shuler CF,Yamazaki K.Hunchback sequence binding protein suppresses mouse TGF-beta3 promoter in vitro.[J].2006,346(3).
[22]Girish R,Seth P,Vaishnav Y,etc.Transforming growth factor beta in hepatitis C virus infection: in vivo and in vitro findings.[J].2003,18(4).
[23]Gutierrez-Ruiz MC,Gomez-Quiroz LE.Liver fibrosis: searching for cell model answers.[J].2007,27(4).
[24]R, Lafyatis,F, Denhez,T, Williams,etc.Sequence specific protein binding to and activation of the TGF-beta 3 promoter through a repeated TCCC motif.[J].1991,19.
[25]Kisseleva T,Brenner DA.Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis.[J].2007,22(Suppl.1).
[26]Bataller R,Brenner DA.Liver fibrosis.[J].2005,115(2).
[27]P, Dít.[Chronic pancreatitis--etiological classifications and diagnostic criteria].[J].2007,53(4).
[28]P J, De Bleser,T, Niki,V, Rogiers,etc.Transforming growth factor-beta gene expression in normal and fibrotic rat liver.[J].1997,26.
[29]Cox DA.TRANSFORMING GROWTH FACTOR-BETA 3 [Review][J].1995,19(5).
[30]Lawrence DA.Latent-TGF-beta: an overview.[J].2001,219(1).
[31]Watanabe S,Nagashio Y,Asaumi H,etc.Pressure activates rat pancreatic stellate cells.[J].2004,287(6).
[32]Kamma C,Anderson I,Carrington LM,etc.Differential regulation of key stages in early corneal wound healing by TGF-beta isoforms and their inhibitors.[J].2006,47(5).
[33]Vogelmann R,Wagner M,Ruf D,etc.Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model.[J].2001,280(1).
[34]G, Demirci,B, Nashan,R, Pichlmayr.Fibrosis in chronic rejection of human liver allografts: expression patterns of transforming growth factor-TGFbeta1 and TGF-beta3.[J].1996,62.
[35]Chang Duck, Kim.[Pancreatitis--etiology and pathogenesis].[J].2005,46(5).