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Relationship of toll-like receptor 4,nuclear factor kappa B and acute pancreatitis

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 25

DOI:: 10.3969/j.issn.1009-3079.2007.25.005

Key Word:: Toll样受体4;核因子кB;急性胰腺炎

Abstract：急性胰腺炎(acute pancreatitis,AP)是一种常见的急重症,经研究证实多种细胞因子的活化与AP的发生进展关系密切.而Toll样受体4(Toll-like receptor 4,TLR4)、核因子-KB(nuclearfactorkappa B,NF-κB)与这些细胞因子的活化密切相关.他们在AP发生发展中作为介导炎症反应的枢纽起着重要作用.以往认为TLR4触发细胞内信号传导通路,从而激活NF-кB,调控大量细胞因子释放,介导炎性反应.目前对TLR4/NF-кB信号通路具体的传导路径及参与因子又有了新的认识,本文概述了TLR4/NF-кB信号通路,且概述了TLR4/NF-кB信号通路相关下调因子、增强因子,及能激活NF-кB的其他因子.

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