You Position: Home > Paper
Current status and advance on T helper cells
( views:205, downloads:83 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 13
- DOI:
- 10.3969/j.issn.1009-3079.2007.13.014
- Key Word:
- 辅助性T细胞;乙型肝炎病毒;免疫
Abstract： CD4+ Th细胞是机体重要的免疫调节细胞,根据其产生细胞因子的不同分为Th1和Th2亚型,分别参与调节细胞免疫和体液免疫.Th1和Th2可相互调节,影响免疫应答的格局.他们来自共同的前体细胞Th0,在不同的细胞因子、抗原等因素的影响下,可发生Th1与Th2的转换.在生理条件下,机体Th1/Th2细胞的免疫功能处于动态平衡,一旦这种平衡发生偏离,机体就会趋向疾病状态.
- [1]Strom TB,Kuchroo VK,Manlongat N,etc.Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.[J].2003,4(11).
- [2]L S, Pri?miagi,V T, Tefanova,T G, Tallo,etc.[Th1-cytokines in chronic hepatitis B and C].[J].1900,47.
- [3]Lloyd AR.Immunopathogenesis of hepatitis C virus infection.[J].2001,79(6).
- [4]Cao T,Sallberg M,Desombere I,etc.In vivo inhibition of anti-hepatitis B virus core antigen (HBcAg) immunoglobulin G production by HBcAg-specific CD4(+) Th1-type T-cell clones in a hu-PBL-NOD/SCID mouse model.[J].2001,75(23).
- [5]Zhou M,Ouyang W.The function role of GATA-3 in Th1 and Th2 differentiation.[J].2003,28(1).
- [6]Smeltz RB,Shevach EM,Hu-Li J,etc.Regulation of interleukin (IL)-18 receptor alpha chain expression on CD4(+) T cells during T helper (Th)1/Th2 differentiation. Critical downregulatory role of IL-4.[J].2001,194(2).
- [7]J, Inobe,A J, Slavin,Y, Komagata,etc.IL-4 is a differentiation factor for transforming growth factor-beta secreting Th3 cells and oral administration of IL-4 enhances oral tolerance in experimental allergic encephalomyelitis.[J].1998,28.
- [8]Rico MA,Subira D,Quiroga JA,etc.Features of the CD4(+) T-cell response in liver and peripheral blood of hepatitis C virus-infected patients with persistently normal and abnormal alanine aminotransferase levels.[J].2002,36(3).
- [9]Lefebvre DE,Chakir H,Webb J,etc.T-bet/GATA-3 ratio as a measure of the Th1/Th2 cytokine profile in mixed cell populations: predominant role of GATA-3.[J].2003,278(1).
- [10]Strober W.Activated STAT4 Has an Essential Role in Th1 Differentiation and Proliferation That Is Independent of Its Role in the Maintenance of IL-12Rbeta2 Chain Expression and Signaling.[J].2002,169(8).
- [11]Rubio M,Sarfati M,Delespesse G,etc.Human monocyte-derived dendritic cells induce naive T cell differentiation into T helper cell type 2 (Th2) or Th1/Th2 effectors. Role of stimulator/responder ratio.[J].2000,192(3).
- [12]Zhu C,Anderson AC,Schubart A,etc.The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity.[J].2005,6(12).
- [13]Herberg J,Maini MK,Williams R,etc.The role of virus-specific CD8(+) cells in liver damage and viral control during persistent hepatitis B virus infection.[J].2000,191(8).
- [14]Dong C,Flavell RA.Th1 and Th2 cells.[J].2001,8(1).
- [15]T, Xing,L, Zhang,Q, Lu.[Predictor of effect of interferon-alpha on patients with hepatitis B: Th1/Th2 type cytokines].[J].2000,80(4).