You Position: Home > Paper
Correlation between the protein expression of reversion inducing cysteine rich protein with Kazal motifs and matrix matalloproteinase-9 in esophageal squamous cell carcinoma and its clinical pathological significance
( views:261, downloads:27 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 10
- DOI:
- 10.3969/j.issn.1009-3079.2007.10.006
- Key Word:
- 基质金属蛋白酶-9;RECK蛋白;食管鳞癌;免疫组化;浸润;转移
Abstract： 目的:探讨RECK及基质金属蛋白酶-9(MMP-9)表达与食管癌发生、发展及浸润、转移的关系.方法:应用免疫组化SP法检测62例食管鳞癌组织、31例癌旁不典型增生组织及62例正常食管黏膜组织中RECK及MMP-9蛋白表达.采用X2检验进行统计学分析.结果:食管鳞癌组织中RECK和MMP-9蛋白表达与癌的组织学分级、浸润深度及淋巴结转移密切相关(χ2=10.422,8.550,4.751;χ2=8.447,14.333,5.373;均P＜0.05).在食管鳞癌癌变过程中RECK蛋白表达在癌组织、癌旁不典型增生组织及正常黏膜组织中的表达率依次增高,分别为59.7%,71.0%,85.5%,组间比较有明显差异(P＜0.01);而MMP-9蛋白在癌组织、癌旁不典型增生组织及正常黏膜组织中的表达率依次降低,分别为80.6%,80.6%,27.4%,组间比较有明显差异(P＜0.01).结论:RECK和MMP-9在食管癌的浸润、转移及黏膜上皮癌变过程中起重要作用,RECK及MMP-9的联合检测可望成为食管鳞癌早期诊断和判断预后的分子指标之一.
- [1]LI Yiqing,ZHANG Yong,ZHENG Qichang.Expression of RECK Gene and MMP-9 in Hilar Cholangiocarcinoma and Its Clinical Significance[J].2005,(5).
- [2].基质金属蛋白酶抑制剂RECK基因在前列腺细胞株中的表达及意义[J].2005,(10).
- [3]Mikala, Egeblad,Zena, Werb.New functions for the matrix metalloproteinases in cancer progression.[J].2002,2(3).
- [4]Noda M,Kondo S,Oh J,etc.RECK: a novel suppressor of malignancy linking oncogenic signaling to extracellular matrix remodeling.[J].2003,22(2).
- [5]王川,张祥福,杨发端,等.NM23基因在食管癌中表达的免疫组化研究[J].1998,(1).
- [6]R M, Sasahara,C, Takahashi,M, Noda.Involvement of the Sp1 site in ras-mediated downregulation of the RECK metastasis suppressor gene.[J].1999,264(3).
- [7]许良中,杨文涛.免疫组织化学反应结果的判断标准[J].1996,(4).
- [8]Brohem CA,Correa TC,Sogayar MC,etc.Higher expression and activity of metalloproteinases in human cervical carcinoma cell lines is associated with HPV presence.[J].2006,84(5).
- [9]Taboga SR,Sogayar MC,Sasahara RM,etc.Downregulation of the RECK-tumor and metastasis suppressor gene in glioma invasiveness.[J].2006,99(1).
- [10]主编李玉林.病理学[M].2004.
- [11]Ikawa Y,Hitomi K,Sheng Z,etc.Regulation of matrix metalloproteinase-9 and inhibition of tumor invasion by the membrane-anchored glycoprotein RECK.[J].1998,95(22).