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Integrons and gene cassettes in antibiotic-resistant Shigella

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
8
DOI:
10.3969/j.issn.1009-3079.2007.08.011
Key Word:
基因盒;整合子;志贺菌;耐药

Abstract´╝Ü 随着抗生素的广泛应用,志贺菌的耐药特别是多重耐药问题日趋严重.具有捕获及表达外来基因能力的整合子(integron)系统作为新的细菌耐药机制,正越来越受关注.根据整合酶int Ⅰ的不同,整合子可分为6类.其中1,2,3类整合子研究较多,并已被证明与细菌的耐药性有关.最近研究表明,2类整合子是志贺菌中最常见的整合子.本文就基因盒-整合子系统的概念、结构及与志贺菌耐药相关性等进行综述.

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