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Effect of H2-receptor blocker combined with domperidone on the blood flow of portal venous system in patients with liver cirrhosis
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 4
- DOI:
- 10.3969/j.issn.1009-3079.2007.04.017
- Key Word:
- 肝硬化;门脉系统;H2受体阻滞剂;多潘立酮;多普勒超声
Abstract： 目的:探讨H2受体阻滞剂联合多潘立酮对肝硬化患者门静脉系统血流量的影响.方法:以20名健康人作为正常对照,60例肝硬化患者随机分成3组,分别给予口服高舒达、口服多潘立酮以及联合用药,治疗前后采用多普勒超声测定门静脉(PVF)、脾静脉(SVF)和肠系膜上静脉(SMVF)血流量(mL/min).结果:治疗后,H2受体阻滞剂组的PVF显著高于治疗前(850.23±140.78 vs 695.22±221.44,P＜0.01),SVF和SMVF低于治疗前,但无显著差异.多潘立酮组PVF较治疗前有增高,无显著差异,而SVF和SMVF显著低于治疗前(SVF:598.13±272.33 vs 816.40±279.61,P＜0.05;SMVF:504.23±1 88.54 vs 640.30±200.12,P＜0.05).联合用药组则PVF显著高于治疗前(876.76±178.65 vs 70534±200.15,P＜0.05),而SVF、SMVF显著低于治疗前(SVF:605.33±252.86 vs 798.33±280.45,P＜0.01;SMVF:503.43±175.25 vs 650.19±190.62,P＜0.01).结论:H2受体阻滞剂组及多潘立酮都具有改善门静脉系统血流的作用,联合应用作用更为明显.
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