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Influence of Salvia miltiorrhiza on the changes of plasma endothelin and P-selectin in patients with acute pancreatitis

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
1
DOI:
10.3969/j.issn.1009-3079.2007.01.014
Key Word:
胰腺炎;内皮素;P-选择素;丹参

Abstract´╝Ü 目的:观察急性胰腺炎(AP)患者血浆内皮素(ET)和P-选择素的变化特点及丹参对其的影响.方法:将82例AP患者随机分为一般治疗组40例和丹参组42例,同时以健康体检者20例作对照组.A组用基础治疗,B组用基础治疗+丹参.采用放射免疫法分别测定血浆ET和P-选择素.结果:重症急性胰腺炎(SAP)组ET和P-选择素显著高于轻型急性胰腺炎(MAP)组和正常组(147.56±10.65 ng/L vs 85.13±9.47,52.27±6.23 ng/L,P<0.01;85.32±6.21 μg/L vs 30.01±4.82,10.26±2.57 μg/L,P<0.01).SAP组ET和P-选择素呈显著正相关(r=0.705,P<0.01).AP患者经一般治疗后ET和P-选择素的水平较治疗前差异无显著性(P>0.05).丹参组治疗后较治疗前ET及P-选择素水平明显下降(69.77±7.65 ng/L vs 100.54±11.41 ng/L,P<0.01;4.07±4.75 μg/L vs 54.52±9.79 μg/L,P<0.01),平均住院日与一般治疗组相比明显缩短(9.76±1.77 d vs 14.27±2.55 d,P<0.01).结论:血浆内皮素和P-选择素参与了AP的发病过程,丹参对AP具有一定的治疗作用.

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