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Clinical values of systemic analysis of peripheral blood mononuclear cell subsets in patients with chronic hepatitis B
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 34
- DOI:
- 10.3969/j.issn.1009-3079.2006.34.016
- Key Word:
- 淋巴细胞;免疫表型;流式细胞术;乙肝病毒;慢性乙型肝炎
Abstract： 目的:系统研究慢性乙型肝炎患者外周血淋巴细胞免疫表型以及与临床的关系.方法:用流式细胞术测定28例慢性乙型肝炎患者外周血单个核细胞膜CD3,CD4,CD5,CD25,CD28及CD38等相关CD分子的表达情况,并与22例健康对照组比较,并分析其与HBVDNA及临床的相关性.结果:28例慢性乙型肝炎患者外周血中CD4+CD25+,CD8+HLADR+CD38+,CD3-CD19+,CD5-CD19+及CD19+CD38+淋巴细胞数明显高于健康对照组(t=2.37,3.71,4.10,2.31,2.17,P＜0.05),而CD3-CD8+,CD8+CD28-及CD3-CD(16+56)+淋巴细胞数明显低于健康对照组(t=3.14,3.20,2.51,P＜0.05).外周血中HBV DNA含量＞109copies/L的患者其CD3+CD8+,CD8+CD28+,CD4+CD45RA+CD62L+,CD8+CD45RA+CD62L+及CD4+CD38+淋巴细胞数均显著高于HBV DNA含量＜109copies/L的患者,差别有统计学意义(t=2.16,2.42,2.83,3.01,2.50,P＜0.01或P＜0.05).结论:慢性乙型肝炎患者T、B两种淋巴细胞的活化程度均较高,NK细胞数量减少;体内HBV复制活跃的患者其T淋巴细胞活化程度较高.
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