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Expression of heat shock protein 70 and 90 and their relationships with biological behaviors of colon cancer
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 33
- DOI:
- 10.3969/j.issn.1009-3079.2006.33.009
- Key Word:
- 结肠癌;热休克蛋白70;热休克蛋白90;生物学行为
Abstract： 目的:探讨HSP70,HSP90在人结肠癌中的表达情况及其和结肠癌细胞生物学行为的相关性.方法:结肠癌患者手术标本40例,分别以癌组织、癌旁2 cm组织和远离癌灶的正常黏膜组织作为病例组和对照组.用亲和免疫组织化学技术方法检测HSP70和HSP90,并收集该40例患者的临床Duke's分期,分析HSP70和HSP90蛋白的阳性程度和结肠癌临床分期是否存在相关性.结果:癌组织HSP70和HSP90的表达明显增高,癌组织、癌旁组织和正常黏膜组织三组之间HSP70和HSP90表达率有明显差异(HSP70:82.5% vs 52.5% vs 25%, x2=26.58,P=0.000;72.5% vs 42.5% vs 22.5%, x2=20.41, P=0.000);HSP70和HSP90蛋白的阳性程度和结肠癌临床分期存在相关性(HSP70:tau_b=0.392, P=0.006; HSP90:tau_b=0.396,P=0.006).结论:结肠癌细胞存在HSP70和HSP90蛋白的过度表达,HSP70,HSP90和结肠癌细胞的生物学行为存在相关性.
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