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Expression of leptin receptor and nuclear factor kappa B and their significances in colorectal adenocarcinoma
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 28
- DOI:
- 10.3969/j.issn.1009-3079.2006.28.004
- Key Word:
- 瘦素受体;核转录因子-κB;结直肠腺癌佑
Abstract： 目的:研究瘦素受体(Ob-R)在结直肠腺癌组织中的表达,探讨Ob-R在肿瘤血管生成中的作用及其可能机制.方法:免疫组织化学方法检测35例结直肠腺癌组织、24例结直肠腺瘤组织和35例正常对照组织中Ob-R、CD105、核转录因子-κBp65(NF-κBp65)的表达,以图像分析软件进行半定量测定.结果:以CD105标记的微血管密度(MVD)在癌症组、腺瘤组、正常对照组间呈递减改变(23.63±2.08 vs 10.83±1.25 vs 1.97±0.37,P＜0.05).Ob-R和NF-κB(p65)的表达部位相似.癌症组中Ob-R和NF-κB(p65)的积分光密度均比对照组高(27.41±2.21 vs 20.45±1.63,45.88±5.46 vs 29.11±3.89,P＜0.05).癌症组中Ob-R,NF-κBp65的积分光密度,MVD三者间呈两两正相关.癌症组63.6%的标本中可见Ob-R血管内皮细胞染色阳性,其MVD较阴性者高(38.21±2.78 vs 27.50±2.95,t=2.602,P＜0.05);68.6%的癌症标本中可见NF-κBp65血管内皮细胞核表达阳性,其MVD较阴性者高(37.53±3.07 vs 28.42±2.63,t=2.146,P＜0.05).Ob-R和NF-κBp65的表达与结直肠腺癌临床病理因素间未见相关性.结论:结直肠腺癌组织中Ob-R表达增多对肿瘤血管生成起促进作用,并且该作用可能是通过NF-κB途径来实现的.
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