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Role of hepatitis B virus X gene and protein

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 26

DOI:: 10.3969/j.issn.1009-3079.2006.26.001

Key Word:: HBV X基因;X蛋白;反式激活

Abstract： HBV X基因编码的X蛋白(PX)是一种多功能蛋白,在HBV感染和肝细胞癌(HCC)发展的不同阶段,执行不同的生物学功能.PX参与调节病毒复制,显著影响肝细胞信号传导、新陈代谢、凋亡、细胞因子产生、细胞周期调控和癌基因、抑癌基因等方面基因表达,干扰线粒体氧化磷酸化等能量代谢过程,造成细胞氧化损伤,促进细胞凋亡.

Reference

[1]Chang-zheng SONG,Zeng-liang Bai,Chang-Cheng Song,etc.Aggregate formation of hepatitis B virus X protein affects cell cycle and apoptosis[J].2003,(7).
[2]王海平,陈孝平,白祥军.Hepatic Cell Apoptosis Was Triggerred by HBx Accumulation and Independent on Verapamil[J].2004,(3).
[3]Jian Guan,Xiao-Ping Chen,HONG Zhu,etc.Involvement of extracellular signal-regulated kinase/mitogen activated protein kinase pathway in multidrug resistance induced by HBx in hepatoma cell line[J].2004,(23).
[4]林静,朱明华,祝峙,等.乙型肝炎病毒X和p53对肝癌细胞生长的影响[J].2003,(1).
[5]陈红英,唐南洪,张生君,等.乙肝病毒X基因真核表达载体的构建及人肝细胞株HL-7702转染[J].2004,(3).
[6]NA Lin,Hong-Ying Chen,DAN Li,etc.Apoptosis and its pathway in X gene-transfected HepG2 cells[J].2005,(28).
[7]李东华,陈孝平,张万广,等.乙型肝炎病毒X基因在体内外对肝癌细胞增殖活性的影响[J].2004,(2).
[8]Schneider RJ,Wolf SK,Melegari M.Hepatitis B virus DNA replication is coordinated by core protein serine phosphorylation and HBx expression[J].2005,79(15).
[9]Gougeon MarieLise,Sitterlin Delphine,Lecoeur Herve,etc.The hepatitis B virus X protein abrogates Bcl-2-mediated protection against Fas apoptosis in the liver.[J].2002,21(3).
[10]Schneider RJ,Su F,Theodosis CN.Role of NF-kappaB and myc proteins in apoptosis induced by hepatitis B virus HBx protein.[J].2001,75(1).
[11]Forgues M,Huo TI,Wang XW,etc.Hepatitis B virus X mutants derived from human hepatocellular carcinoma retain the ability to abrogate p53-induced apoptosis.[J].2001,20(28).
[12]Li D,Lin N,Tao QM,etc.A novel hepatitis B virus X-interactive protein: cytochrome C oxidase III.[J].2006,21(4).
[13]Doria M.,Benn J.,Su F.,etc.Hepatitis B Virus Hbx Protein Induces Transcription Factor Ap-1 by Activation of Extracellular Signal-Regulated and C-Jun N-Terminal Mitogen-Activated Protein Kinases[J].1996,70(8).
[14]Hyun Jin Kwun,Kyung Lib Jang.Natural variants of hepatitis B virus X protein have differential effects on the expression of cyclin-dependent kinase inhibitor p21 gene[J].2004,32(7).
[15]Chang ZG,Tao YM,Tang FQ,etc.Hepatocellular carcinoma cells containing hepatitis B virus X protein have enhanced invasive potential conditionally.[J].2006,38(4).
[16]Liang TJ,Kim JW,Huang Y,etc.Altered proteolysis and global gene expression in hepatitis B virus X transgenic mouse liver.[J].2006,80(3).
[17]Bo XC,Sun DC,Lou S,etc.HBx protein of hepatitis B virus (HBV) can form complex with mitochondrial HSP60 and HSP70.[J].2005,150(8).
[18]Liang TJ,Protzer U,Jacob J,etc.Inhibition of cellular proteasome activities enhances hepadnavirus replication in an HBX-dependent manner[J].2004,78(9).
[19]Rahmani Z,Siddiqui A,Huh KW,etc.Hepatitis B virus X protein colocalizes to mitochondria with a human voltage-dependent anion channel, HVDAC3, and alters its transmembrane potential.[J].2000,74(6).
[20]Kim SI,Park M,Kim M,etc.Efficient inhibition of hepatitis B virus replication by small interfering RNAs targeted to the viral X gene in mice.[J].2006,119(2).
[21]Lee H,Kim H,Yun Y.X-gene product of hepatitis B virus induces apoptosis in liver cells.[J].1998,273(1).
[22]J C, Reed.Bcl-2 family proteins.[J].1998,17(25).
[23]Reddi H,Mathur M,Panda SK,etc.Hepatocellular carcinoma in a hepatitis B 'x' transgenic mouse model: A sequential pathological evaluation.[J].2003,18(1).
[24]Yu D,Kim Y,Lee M,etc.Hepatitis B virus X protein induced expression of interleukin 18 (IL-18): a potential mechanism for liver injury caused by hepatitis B virus (HBV) infection.[J].2002,37(3).
[25]Shirakata Y,Koike K.Hepatitis B virus X protein induces cell death by causing loss of mitochondrial membrane potential.[J].2003,278(24).
[26]Hoare J.,King IA.,McGarvey MJ.,etc.Intracellular localization of the hepatitis B virus HBx protein[J].2001,82(4).
[27]N P, Klein,R J, Schneider.Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras.[J].1997,17.
[28]Huang FJ,He F,Tang H,etc.The transcriptional transactivation function of HBx protein is important for its augmentation role in hepatitis B virus replication[J].2005,79(9).
[29]Park SG,Lim SO,Jung G,etc.The hepatitis B virus X protein up-regulates lymphotoxin alpha expression in hepatocytes[J].2005,1741(1).
[30]Bouchard MJ,Wang LH,Schneider RJ.Activation of focal adhesion kinase by hepatitis B virus HBx protein: Multiple functions in viral replication[J].2006,80(9).
[31]Yun C,Lee JH,Cho H,etc.Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway.[J].2004,2(3).
[32]Siddiqui A,Maguire HF,Qadri I.Hepatitis B virus transactivator protein X interacts with the TATA-binding protein.[J].1995,92(4).
[33]Yun Y,Lee YH.HBx protein of hepatitis B virus activates Jak1-STAT signaling.[J].1998,273(39).
[34]Schaefer S,Gerlich WH,Schuster R.Induction of apoptosis by the transactivating domains of the hepatitis B virus X gene leads to suppression of oncogenic transformation of primary rat embryo fibroblasts.[J].2000,19(9).
[35]Kim DG.,Im JH.,Hwang JM.,etc.Human hepatitis B virus-X protein alters mitochondrial function and physiology in human liver cells[J].2004,279(15).
[36]Strubin M,Bontron S,Lin Marq N.Hepatitis B virus X protein associated with UV-DDB1 induces cell death in the nucleus and is functionally antagonized by UV-DDB2.[J].2002,277(41).
[37]Yoo YG,Lee MO.Hepatitis B virus X protein induces expression of Fas ligand gene through enhancing transcriptional activity of early growth response factor.[J].2004,279(35).
[38]Saetta AA,Korkolopoulou P,Voutsinas G,etc.c-FLIP expression in bladder urothelial carcinomas: its role in resistance to Fas-mediated apoptosis and clinicopathologic correlations.[J].2004,63(6).
[39]Kalra N,Kumar V.c-Fos is a mediator of the c-myc-induced apoptotic signaling in serum-deprived hepatoma cells via the p38 mitogen-activated protein kinase pathway.[J].2004,279(24).
[40]Leupin O,Strubin M,Bontron S,etc.Hepatitis B virus X protein stimulates viral genome replication via a DDB1-dependent pathway distinct from that leading to cell death.[J].2005,79(7).
[41]Giannini C,Tu H,Carnot F,etc.Paracrine in vivo inhibitory effects of hepatitis B virus X protein (HBx) on liver cell proliferation: an alternative mechanism of HBx-related pathogenesis.[J].2002,99(10).
[42]Pauleau AL,Gonzalez-Polo RA,Boya P,etc.Viral proteins targeting mitochondria: controlling cell death[J].2004,1659(2).
[43]Seong BL,Kim KH.Pro-apoptotic function of HBV X protein is mediated by interaction with c-FLIP and enhancement of death-inducing signal.[J].2003,22(9).
[44]Wang LH.,Puro RJ.,Bouchard MJ.,etc.Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication[J].2003,77(14).
[45]Perez MH,Alaoui-Jamali MA,Jaitovich-Groisman I,etc.Transcriptional regulation of the TFIIH transcription repair components XPB and XPD by the hepatitis B virus x protein in liver cells and transgenic liver tissue.[J].2001,276(17).
[46]Lee SG,Rho HM.Transcriptional repression of the human p53 gene by hepatitis B viral X protein.[J].2000,19(3).
[47]Kumar V,Goswami SK,Majumdar SS,etc.Sustained activation of mitogen-activated protein kinases and activator protein 1 by the hepatitis B virus X protein in mouse hepatocytes in vivo.[J].2001,75(21).
[48]Graessmann M,Graessmann A,Guhl E,etc.HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53.[J].2003,22(19).
[49]You J,Ye L,Zhang H,etc.Hepatitis B virus X protein upregulates survivin expression in hepatoma tissues.[J].2005,77(3).
[50]Levrero M,Fulco M,Graessmann A,etc.The hepatitis B virus HBx protein inhibits caspase 3 activity.[J].1998,273(50).
[51]Bouillet P.,Strasser A..BH3-only proteins - evolutionarily conserved proapoptotic Bcl-2 family members essential for initiating programmed cell death[J].2002,115(8).
[52]Terradillos, Oliver,Pollicino, Teresa,Lecoeur, Hervé,etc.p53-independent apoptotic effects of the hepatitis B virus HBx protein in vivo and in vitro.[J].1998,17(16).