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Correlations of lymphatic vessel endothelial hyaluronan receptor-t, intercellular adhesion molecular-1 and lymphocyte function associated antigen-1 expression with lymphatic metastasis in colon adencarcinoma
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 24
- DOI:
- 10.3969/j.issn.1009-3079.2006.24.009
- Key Word:
- 腺癌;结肠;黏附分子;淋巴管;转移
Abstract： 目的:探讨癌细胞淋巴管转移机制,观察细胞黏附分子LYVE-1,ICAM-1及LFA-1在结肠腺癌组织及淋巴管的表达.方法:结肠腺癌患者术后组织标本60例,其中淋巴结转移30例,无淋巴结转移30例,运用免疫组织化学的方法检测LYVE-1,ICAM-1及LFA-1在结肠腺癌组织及淋巴管的表达.结果:有淋巴结转移组的结肠腺癌淋巴管数密度(5.05±1.57 vs 3.45±1.84,P＜0.01)和吸光度(0.231±0.078 vs 0.196±0.089,P＜0.05)均比无淋巴结转移组增加,单个淋巴管的平均面积减少;ICAM-1在淋巴结转移组结肠腺癌的癌细胞中表达上调(0.069±0.036 vs 0.017±0.012,P＜0.01),淋巴管不表达;LFA-1在结肠腺癌的血管及转移组部分淋巴管内皮上有表达.结论:LYVE-1,ICAM-1及LFA-1在人结肠腺癌中的表达,可能与淋巴管增生和扩张,促进癌细胞的淋巴转移有关.
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