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Single nucleotide polymorphism of interferon-gamma gene +874 T/A in colorectal cancer

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
20
DOI:
10.3969/j.issn.1009-3079.2006.20.015
Key Word:
干扰素;大肠肿瘤;多态性

Abstract´╝Ü 目的:探讨中国浙江地区汉族人群中IFN-γ基因+874位点多态性分布,分析其与大肠癌的相关性.方法:应用突变特异性扩增系统(ARMS)-PCR对健康者132例和大肠癌患者92例IFN-γ基因+874位点多态性进行分析,并将PCR产物克隆及测序鉴定.结果:大肠癌患者IFN-γ+874位点AA基因型频率为70.6%,显著高于正常人中的57.6%(P<0.05).进一步分析显示IFN-γ+874位点AA基因型与患者的年龄、性别、肿瘤部位、Dukes分期无关.结论:IFN-γ+874位点AA基因型可能与大肠癌的发生相关.

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