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Advance in factors associated with activation of pancreatic stellate cells

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 20

DOI:: 10.3969/j.issn.1009-3079.2006.20.012

Key Word:: 胰腺星状细胞;胰腺纤维化

Abstract：胰腺纤维化是慢性胰腺炎主要的病理学变化,而活化的胰腺星状细胞(PSC)是纤维化过程的主要效应细胞.多种细胞因子,如转化生长因子-β1(TGF-β1)、结缔组织生长因子(CTGF)、血小板衍化生长因子(PDGF)、白细胞介素-10(IL-10)等及氧自由基,细胞内压力等因素,通过各自的作用来影响PSC的活性.最终通过有丝分裂原活化蛋白激酶途径(MAPK)、Smad信号转导蛋白、过氧化物酶体增生物激活受体-γ(PPAR-γ)等细胞内信号调节PSC的活化及胰腺炎症和纤维化过程.

Reference

[1]LI-JUAN ZHANG,Wei-Da Zheng,Mei-Na Shi,etc.Effects of interleukin-10 on activation and apoptosis of hepatic stellate cells in fibrotic rat liver[J].2006,(12).
[2]刘成海,刘平,胡义扬,等.丹酚酸B盐对转化生长因子-β1刺激肝星状细胞活化与胞内信号转导的作用[J].2002,(18).
[3]施新岗,李兆申,贾一韬,等.大鼠重症急性胰腺炎发病机制中p38丝裂原活化蛋白激酶的作用[J].2005,(5).
[4]F U Weiss,P Simon,H Witt,etc.SPINK1 mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutations[J].2003,40(4).
[5]Klonowski Stumpe H,Fischer R,Luthen R,etc.Apoptosis in activated rat pancreatic stellate cells.[J].2002,283(3).
[6]Kikuta K,Kume K,Satoh M,etc.Differential roles of signaling pathways for proliferation and migration of rat pancreatic stellate cells.[J].2003,199(2).
[7]ten Dijke-P,Heldin CH,Miyazono K.Signaling inputs converge on nuclear effectors in TGF-beta signaling.[J].2000,25(2).
[8]Yun-wei, Sun,Yong-ping, Zhang,Min-min, Qiao,etc.[The study of regulation of connective tissue growth factor gene promoter by transforming growth factor beta1 in pancreatic stellate cells].[J].2004,84.
[9]Vogelmann R,Wagner M,Ruf D,etc.Effects of fibrogenic mediators on the development of pancreatic fibrosis in a TGF-beta1 transgenic mouse model.[J].2001,280(1).
[10]Max G. Bachem*,Erik Schneider*,Hans Groß*,etc.Identification, culture, and characterization of pancreatic stellate cells in rats and humans[J].1998,115(2).
[11]Schnekenburger Jurgen,Domschke Wolfram,Simon Peter,etc.Hereditary pancreatitis caused by a novel PRSS1 mutation (Arg-122 --> Cys) that alters autoactivation and autodegradation of cationic trypsinogen.[J].2002,277(7).
[12]P S, Haber,G W, Keogh,M V, Apte,etc.Activation of pancreatic stellate cells in human and experimental pancreatic fibrosis.[J].1999,155(4).
[13]Ichimura M,Emori Y,Matsumura N,etc.Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in rats.[J].2005,20(6).
[14]M V Apte,P S Haber,S J Darby,etc.Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesis[J].1999,44(4).
[15]Mizushima T,Harada H,Matsumura N,etc.Study on free radicals and pancreatic fibrosis--pancreatic fibrosis induced by repeated injections of superoxide dismutase inhibitor.[J].2001,22(1).
[16]P, Tontonoz,E, Hu,B M, Spiegelman.Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor.[J].1994,79.
[17]Satoh Y,Sato K,Sugano K,etc.Autocrine loop between TGF-beta1 and IL-1beta through Smad3- and ERK-dependent pathways in rat pancreatic stellate cells.[J].2006,290(4).
[18]Tetsu, Okamoto,Tamaki, Yamada,Atsushi, Kuno,etc.FTY720, an immunosuppressant, attenuates chronic pancreatitis in rats by suppressing T-cell infiltration.[J].2005,30.
[19]Brock P,Jaster R,Sparmann G,etc.Inhibition of pancreatic stellate cell activation by the hydroxymethylglutaryl coenzyme A reductase inhibitor lovastatin.[J].2003,65(8).
[20]Schmid Kotsas-A,Luttenberger T,Siech M,etc.Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: implications in pathogenesis of pancreas fibrosis.[J].2000,80(1).
[21]Ahn BO,Yoo BM,Kim WH,etc.Novel antioxidant ameliorates the fibrosis and inflammation of cerulein-induced chronic pancreatitis in a mouse model.[J].2005,5(2).
[22]Jaskiewicz K,Rzepko R,Nalecz A,etc.Immunocytes and activated stellate cells in pancreatic fibrogenesis.[J].2003,26(3).
[23]Lou H,Kaur K,Sharma AK,etc.Adriamycin-induced oxidative stress, activation of MAP kinases and apoptosis in isolated cardiomyocytes.[J].2006,13(2).
[24]Kikuta K,Satoh A,Satoh M,etc.Inhibition of p38 mitogen-activated protein kinase blocks activation of rat pancreatic stellate cells.[J].2003,304(1).
[25]Kawamata H,Kobayashi M,Shimizu K,etc.Troglitazone inhibits the progression of chronic pancreatitis and the profibrogenic activity of pancreatic stellate cells via a PPARgamma-independent mechanism.[J].2004,29(1).
[26]Apte MV,Doherty E,Phillips PA,etc.Pancreatic stellate cell activation by ethanol and acetaldehyde: is it mediated by the mitogen-activated protein kinase signaling pathway?[J].2003,27(2).
[27]Ishii H.Xanthine oxidase-derived oxygen radicals play significant roles in the development of chronic pancreatitis in WBN/Kob rats.[J].2002,17(5).
[28]Quertinmont E,Delhaye M,Geerts A,etc.Endogenous interleukin-10 modulates fibrosis and regeneration in experimental chronic pancreatitis.[J].2002,282(6).
[29]Schmid RM,Adler G,Zhao J,etc.Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cells.[J].2001,281(2).
[30]Watanabe S,Nagashio Y,Asaumi H,etc.Pressure activates rat pancreatic stellate cells.[J].2004,287(6).
[31]Kazuhiro Kikuta,Masahiro Satoh,Akihiko Satoh,etc.Alcohol Activates Activator Protein-1 and Mitogen-Activated Protein Kinases in Rat Pancreatic Stellate Cells[J].2002,302(1).
[32]Zhou FH,Foster BK,Zhou XF,etc.TNF-alpha mediates p38 MAP kinase activation and negatively regulates bone formation at the injured growth plate in rats.[J].2006,21(7).
[33]Nagashio Y,Asaumi H,Otsuki M,etc.Inhibition of transforming growth factor beta decreases pancreatic fibrosis and protects the pancreas against chronic injury in mice.[J].2004,84(12).
[34]Ueda N.,Kita H.,Satoh Y.,etc.Distinct roles of Smad2-, Smad3-, and ERK-dependent pathways in transforming growth factor-beta(1) regulation of pancreatic stellate cellular functions[J].2004,279(10).