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Clinical study on combined chemotherapy of oxaliplatin or hydroxycamptothecine plus 5-fluorouracil and leucovorin for advanced colorectal cancer
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 19
- DOI:
- 10.3969/j.issn.1009-3079.2006.19.008
- Key Word:
- 草酸铂;羟基喜树碱;5-氟尿嘧啶;结直肠癌
Abstract： 目的:比较草酸铂及羟基喜树碱联合亚叶酸钙、氟尿嘧啶治疗进展期结直肠癌的近期疗效、不良反应和生存期.方法:经病理证实的进展期结直肠癌病例60例,40例(OLF组)采用草酸铂联合亚叶酸钙和氟尿嘧啶方案化疗92个周期,20例(HLF组)采用羟基喜树碱联合亚叶酸钙和氟尿嘧啶方案化疗40个周期,观察化疗不良反应,2-3周期后评价疗效,随访观察无疾病进展生存期、总生存期,统计1a生存率.结果:OLF和HLF组近期有效率分别为30.0%(12/40)和25.0%(5/20),无统计学差异(χ2=0.531,P=0.811);中位无疾病进展生存期分别为6.4和7.3 mo,无统计学差异(u=1.5088,P＞0.05);中位总生存期分别为10.2和10.8 mo,无统计学差异(u=0.3487,P＞0.05);1a生存率分别为34.09%和38.55%,无统计学差异(u=0.3275,P＞0.05).两组间Ⅲ,Ⅳ度不良反应均以骨髓抑制和消化道反应为主,其中腹泻发生率HLF组高于OLF组,有统计学差异(χ2=7.876,P=0.044).结论:OLF和HLF两方案治疗进展期结直肠癌疗效相似,前者外周神经毒性较常见,后者腹泻更常见.
- [1]赵雷,钟立松,陈兆红.以奥沙利铂和以羟基喜树碱为主方案治疗晚期大肠癌的疗效观察[J].2003,(4).
- [2]刘细平,王严庆,汤为学.大肠癌对顺铂、5-氟尿嘧啶、羟基喜树碱的敏感性与P-糖蛋白表达的研究[J].2003,(2).
- [3]黄慧强,姜文奇,胡晓桦,等.羟基喜树碱冻干粉针（拓僖）单药治疗晚期恶性肿瘤临床研究的初步报告[J].2003,(12).
- [4]张开芳.草酸铂联合亚叶酸钙及5_氟脲嘧啶治疗晚期大肠癌30例临床观察[J].2003,(6).
- [5]杨家梅,李苏宜,李英昭.难治性晚期大肠癌加用羟基喜树碱治疗21例疗效及毒性分析[J].1999,(11).
- [6]项永兵.肿瘤登记资料的统计分析[J].2001,(5).
- [7]杨润祥,马飞.奥沙利铂的神经毒性及其防治[J].2005,(3).
- [8]A B, Miller,B, Hoogstraten,M, Staquet,etc.Reporting results of cancer treatment.[J].1981,47(1).
- [9]Ruiwen Zhang,Yufeng Li,Qiuyin Cai,etc.Preclinical pharmacology of the natural product anticancer agent 10-hydroxycamptothecin, an inhibitor of topoisomerase I[J].1998,41(4).
- [10]Lepille D,Marre A,Rougier P,etc.Antitumour activity of three second-line treatment combinations in patients with metastatic colorectal cancer after optimal 5-FU regimen failure: a randomised, multicentre phase II study.[J].2002,13(10).
- [11]主编姚阳.恶性肿瘤的诊断与综合治疗[M].2005.
- [12]Driver RW,Yang LX.Synthesis and pharmacology of new camptothecin drugs.[J].2005,5(5).
- [13]陆建伟,黄富麟,郑秀立,等.含羟基喜树碱联合治疗方案治疗晚期胃肠道癌临床观察[J].1998,(3).
- [14]Garay CA,Rothenberg ML,Hart LL,etc.Superiority of Oxaliplatin and Fluorouracil-Leucovorin Compared With Either Therapy Alone in Patients With Progressive Colorectal Cancer After Irinotecan and Fluorouracil-Leucovorin: Interim Results of a Phase III Trial.[J].2003,21(11).
- [15]Li M,Xiao D,Ding J,etc.Antiangiogenic potential of 10-hydroxycamptothecin.[J].2001,69(14).
- [16]Johnson SW,O'Dwyer PJ.Current status of oxaliplatin in colorectal cancer.[J].2003,30(3 Suppl.6).
- [17]Park SH,Sung JY,Han SH,etc.Oxaliplatin, folinic acid and 5-fluorouracil (FOLFOX-4) combination chemotherapy as second-line treatment in advanced colorectal cancer patients with irinotecan failure: a Korean single-center experience.[J].2005,35(9).
- [18]刘键.羟基喜树碱类药物作用机制及在合并治疗中机理的研究[J].1998,(5).
- [19]Tournigand C,Molitor JL,Krulik M,etc.Evaluation of oxaliplatin dose intensity in bimonthly leucovorin and 48-hour 5-fluorouracil continuous infusion regimens (FOLFOX) in pretreated metastatic colorectal cancer. Oncology Multidisciplinary Research Group (GERCOR).[J].2000,11(11).