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Numbers and activities of CD56+T cells and natural killer cells in cirrhotic livers with hepatitis C
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 18
- DOI:
- 10.3969/j.issn.1009-3079.2006.18.018
- Key Word:
- 丙型肝炎;肝硬化;CD56+T细胞;NK细胞;细胞数量;细胞活性
Abstract： 目的:研究CD56+T细胞和NK细胞在丙型肝炎肝硬化时的数量及抗肿瘤细胞活性变化.方法:丙型肝炎肝硬化患者18例,快速肝穿获得肝组织,分离肝脏单个核细胞(MNC),流式细胞仪分析CD56+T细胞及NK细胞数量,肝脏MNC和外周血单个核细胞(PBMC)分别与IL-2混合培养,检测IFN-γ含量及抗肿瘤细胞活性.结果:健康志愿者、慢性丙型肝炎患者、丙型肝炎肝硬化患者肝脏MNC中CD56+T细胞数量百分比分别是20.4%±6.2%,11.2%±3.1%和5.0%±1.6%;NK细胞比例分别是31.1%±9.7%,31.6%±8.3%和18.3%±5.4%;肝脏MNC的IFN-γ产量分别是7.4±2.4,3.2±1.8和1.9±0.5μg/L;抗肿瘤细胞的细胞毒性分别是61.1%±17.1%,59.2%±14.6%,26.7%±8.5%.以上四组数据均以肝炎肝硬化患者变化最为显著(P＜0.05).结论:丙型肝炎肝硬化时肝脏CD56+T细胞和NK细胞数量及抗肿瘤细胞活性分别下降.
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