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Advance in research of insulin resistance and nonalcoholic fatty liver disease

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 12

DOI:: 10.3969/j.issn.1009-3079.2006.12.013

Key Word:: 胰岛素抵抗;非酒性脂肪性肝病;TNF-α;脂联素;瘦素

Abstract：非酒精性脂肪性肝病(NAFLD)是现在临床上最为常见的肝病之一,其病因及发病机制均相当复杂,至今尚未完全阐明.目前认为,胰岛素抵抗(IR)不仅是NAFLD的触发因素,而且还可能间接促进单纯性脂肪肝向脂肪性肝炎(NASH)乃至肝纤维化转变的过程.至于IR是否直接参与NASH的发生、发展尚存在争议.此外,NAFLD本身也可能诱发及加重IR,比如肝细胞内蓄积的脂肪、TNF-α、瘦素抵抗等都参与这一过程.随着二者关系及相关因素的发展,NAFLD在诊疗方面也取得了较大的进展.近年来,有关这方面的研究很多,本文对此作阐述.

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