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Progress of lymph angiogenesis in digestive malignant tumor

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 9

DOI:: 10.3969/j.issn.1009-3079.2006.09.011

Key Word:: 恶性肿瘤;淋巴管生成;血管内皮生长因子;消化道

Abstract：消化道恶性肿瘤的发病率日益增高,而肿瘤的淋巴道转移是导致患者最终死亡的重要因素之一.在某些恶性肿瘤中已经证实有淋巴管生成,被称为淋巴管生成因子的VEGF-C、VEGF-D及其受体VEGFR-3能够诱导淋巴管的生成.恶性肿瘤中的淋巴管生成因子不但能够促进肿瘤淋巴管的生成,而且与淋巴道转移密切相关.近年来对于消化道恶性肿瘤的淋巴管生成以及淋巴道转移的研究正在开展,本文将对消化道恶性肿瘤淋巴管生成机制,淋巴管生成与肿瘤淋巴道转移的关系,最新研究进展以及此项研究的临床意义加以综述.

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