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Effect of vitamin A on hepatic cirrhosis in patients with chronic alcoholic liver disease
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1009-3079.2006.02.021
- Key Word:
- 视黄醇脂;胶原;血清Ⅲ型前胶原肽;血清透明质酸
Abstract： 目的:证明维生素A(Vit A)对慢性酒精性肝病(ALD)患者的肝脏纤维化形成有抑制作用,为肝纤维化的治疗提供一条简便有效的新途径.方法:选择58例ALD患者,采用临床观察的方法,通过外源性的给予Vit A,以酶联免疫吸附法检查ALD患者血清Ⅲ型前胶原肽(PⅢP)及血清透明质酸(HA)的变化.结果:Vit A可以降低ALD患者血清Ⅲ型前胶原肽及血清透明质酸水平.Vit A治疗后18 mo,血清Ⅲ型前胶原肽(16.9±6.8μg/Lvs28.2±9.7μg/L)及透明质酸(132.3±71 μg/Lvs 210.0±87μg/L)水平均较治疗前显著降低(均P＜0.01),且较对照组也有显著降低(PⅢP:16.9±6.8μg/L vs 23.6±9.6 μg/L,P＜0.01;HA:132.3±71μg/L vs 192.0±97 μg/L,P＜0.05).结论:Vit A可以抑制ALD患者肝脏纤维化的形成,其机制可能是Vit A参与肝星状细胞(HSC)的代谢,从而抑制胶原的释放.
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