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Role of β-catenin centered Wnt signaling pathway in occurrence of digestive tract tumors

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 24

DOI:: 10.3969/j.issn.1009-3079.2005.24.010

Key Word:: β-catenin;Wnt信号通路;消化道肿瘤

Abstract： Wnt家族基因编码一组糖蛋白信号分子,这些糖蛋白分子激活的信号通路在人类不同肿瘤中的作用是相互交织的.β-catenin是Wnt信号通路正向调节重要效应物,其胞质内降解的失调及核内累积激活一系列靶基因的转录导致肿瘤的发生.这个过程中许多成分质和量的改变与临床不同病理指标有关,了解这条通路在肿瘤发生过程中具体的分子机制有助于为临床诊断提供依据,为早期干预治疗提供方法.

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