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CD14基因C-260T多态性与溃疡性结肠炎的相关性

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Author:
No author available
Journal Title:
WORLD CHINESE JOURNAL OF DIGESTOLOGY
Issue:
12
DOI:
10.3969/j.issn.1009-3079.2005.12.021
Key Word:
No keyword available

Abstract´╝Ü 目的:研究我国湖北汉族人CD14基因C-260T多态性的分布及CD14基因C-260T位点的突变是否与溃疡性结肠炎(UC)相关.方法:采用PCR-RFLP方法检测114例UC患者以及160例正常对照者CD14-260基因型及等位基因频率.结果:对上述274份DNA标本的基因型分析,发现CD14-260基因型在正常对照组与UC组间无显著性差异.此基因多态性与UC无相关性.结论:CD14基因C-260T多态性与中国湖北汉族UC无明显相关性.CD14基因不是溃疡性结肠炎的易感基因.

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