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Expression of p21WAF1 and Bax in gastrointestinal stromal tumors and its clinical significance
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 11
- DOI:
- 10.3969/j.issn.1009-3079.2004.11.029
- Key Word:
- No keyword available
Abstract： 目的:探讨p21WAF1和Bax的表达与胃肠道间质瘤的临床病理学特征的关系,分析p21WAF1和Bax在GIST中的作用及其相关性.方法:应用免疫细化SP法观察40例胃肠道间质瘤中p2IWAF1和Bax的表达情况.结果:在GIST 40例中,21例表达p21WAF1,阳性表达率为52.5%,p21WAF1阳性信号定位于细胞核;22例表达Bax,阳性表达率55.0%,Bax阳性信号定位于细胞质.p21WAF1和Bax的表达与GIST的性别、年龄、部位、肿瘤大小、有无坏死、组织学分型无关,与组织学分级有关(X2=20.217,P=0.000＜0.01;X2=22.896,P=0.000＜0.01).p21WAF1和Bax在潜在恶性和恶性GIST中表达较高,而在良性GIST表达较低(80.0%,80.0%,6.7%和90.0%,80.0%,6.7%).进一步通过两两比较,良性和潜在恶性之间,良性和恶性之间表达率P21WAF1和Bax表达率有显著差别(P＜0.01),但潜在恶性和恶性之间P21WAF1和Bax的表达率无显著性差异.p21WAF1和Bax的表达具有一定的正相关性(r=0.448,x2=8.021,P=0.005,Kappa=0.447).结论:p21WAF和Bax在潜在恶性和恶性GIST中发挥作用,但在良性GIST中不发挥作用,二者可作为区别GIST良恶性的指标.
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