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胃癌及癌前病变中胃黏膜上皮细胞增生及凋亡相关基因蛋白表达
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 2
- DOI:
- 10.3969/j.issn.1009-3079.2004.02.070
- Key Word:
- No keyword available
Abstract： 目的:探讨胃癌演变过程中胃上皮细胞动力学变化.方法:应用免疫组化SP法对各种病变胃上皮细胞增生相关蛋白(PCNA、P53)和凋亡相关蛋白(Fas、Bcl-2、Bax)的表达进行检测.结果:PCNA、P53表达随病变进展逐渐增加,慢性浅表性胃炎(CSG)组明显低于肠化生(IM)、不典型增生(Dys)、胃癌(GC)组(PCNA 53.3%vs75.6%、93.3%、86.4%,P53 3.3%vs24.4%、36.7%、81.8%).Fas、Bax表达随病变进展逐渐减少,Dys、GC组明显低于CSG组(Fas 30%、27.3%vs60%,Bax 43.3%、40.9%vs70%,P＜0.05).Bcl-2表达随病变进展而逐渐增加,Dys(633%)、GC(72.7%)组明显高于CSG(20%)、IM(32.2%)组(P＜0.01).结论:对不同胃黏膜上皮细胞增生相关蛋白(PCNA、P53)及凋亡相关蛋白(Fas、Bcl-2、Bax)检测表明,在胃癌演变过程中存在着胃上皮细胞增生和凋亡的失衡,即增生过快凋亡受抑.PCNA、P53、Fas、Bcl-2、Bax通过在不同病变阶段被激活或抑制而在胃癌及癌前病变形成过程中起作用.
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