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Expression of cyclooxygenase-2 in pancreaticcancer and its correlation with p53

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Author:: No author available

Journal Title:: WORLD CHINESE JOURNAL OF DIGESTOLOGY

Issue:: 2

DOI:: 10.3969/j.issn.1009-3079.2003.02.023

Key Word:: No keyword available

Abstract：目的探讨环氧化酶-2(COX-2)和p53在胰腺癌组织中的表达与生物学行为之间的关系并探讨二者的相关性及可能机制.方法:用免疫组织化学Envision法对51例胰腺导管癌和11例癌旁非肿瘤胰腺组织的COX-2和p53的表达进行检测.结果:51例胰腺导管癌中COX-2和p53蛋白的表达率分别为74.5%和60.8%;二者在11例癌旁非肿瘤胰腺组织中均未发现阳性表达.COX-2的表达与临床分期和淋巴结转移有关(P＝0.022,0.036),而与组织学分级关系不大(P＝0.152);p53的表达与淋巴结转移有关(P＝0.035),而与组织学分级、临床分期关系不大(P＝0.131,0.078);COX-2的表达与p53的表达密切相关(r=452,P＝0.001).二者的表达与患者的性别、年龄、肿瘤的大小、部位均无关.结论:COX-2和p53的协同作用可能在胰腺癌的发生发展过程中起重要作用,可能为胰腺癌的治疗提供了新的靶点.

Reference

[1]Lun-Xiu Qin,Zhao-You Tang,Zeng-Chen Ma,etc.P53 immunohistochemical scoring: an independent prognostic marker for patients after hepatocellular carcinoma resection[J].2002,(3).
[2]王东旭,房殿春,李为,等.胃幽门螺杆菌感染与抑癌基因失活的关系[J].2001,(9).
[3]季代金,曹燕,张亚历,等.大肠癌HT-29,Lovo细胞P 53转录表达差异同步研究[J].2000,(1).
[4]Yun-Lin Wu,Bo Sun,Xue-jun Zhang,etc.Growth inhibition and apoptosis induction of Sulindac on Human gastric cancer cells[J].2001,(6).
[5]张智勇,窦科峰,刘正才.肝外胆管癌中p73与p53蛋白表达的相关性[J].2001,(10).
[6]Xin WANG,MEI Lan,Han-Ping Wu,etc.Direct effect of croton oil on intestinal epithelial cells and colonic smooth muscle cells[J].2002,(1).
[7]魏子白,王丽冰,田步生,等.内镜下卢戈液染色与P53蛋白检测诊断早期食管癌[J].2001,(5).
[8]吴清明,李胜保,王强,等.食管癌环氧化酶-2高表达与临床病理特征的关系[J].2001,(1).
[9]庄则豪,王立东.非甾体类抗炎药与消化道肿瘤[J].2001,(9).
[10]郜恒骏,于连珍,孙亮,等.胃癌及癌旁组织中COX-2基因蛋白的表达[J].2000,(5).
[11]An Gao Xu,Shao Guang Li,Ji Hong Liu,etc.Function of apoptosis and expression of the proteins Bcl-2, p53 and C-myc in the development of gastric cancer[J].2001,(3).
[12]李建英,于皆平,罗和生,等.非甾体类抗炎药对胃癌SGC7901细胞增生及环氧合酶活性的影响[J].2002,(3).
[13]Li Ping Wang,KE Liang,Yu Shen,etc.Neutron-induced apoptosis of HR8348 cells in vitro[J].2001,(3).
[14]Lun-Xiu Qin,Zhao-You Tang.The prognostic molecular markers in hepatocellular carcinoma[J].2002,(3).
[15]刘节,陈素兰,张伟,等.食管癌P21WAF1表达与P53突变的关系[J].2000,(12).
[16]Geng Tian,Jie-Ping Yu,He-Sheng Luo,etc.Effect of Nimesulide on proliferation and apoptosis of human hepatoma SMMC-7721 cells[J].2002,(3).
[17]Hong-liang LI,Dan-Dan Chen,Xiao-hong LI,etc.Changes of NF-kB, p53, Bcl-2 and caspase in apoptosis induced by JTE-522 in human gastric adenocarcinoma cell line AGS cells: role of reactive oxygen species[J].2002,(3).
[18]范如英,李世荣,武子涛,等.散发性大肠癌组织及粪便P53蛋白、K-ras及APC基因的检测[J].2001,(7).
[19]吴汉平,吴开春,李玲,等.人环氧合酶-2（hCOX-2）编码基因的克隆及其反义核酸转染胃癌细胞的初步研究[J].2000,(11).
[20]孙波,吴云林,张学军,等.舒林酸抑制人胃腺癌细胞增殖及诱导凋亡[J].2001,(9).
[21]刘节,苏勤,张伟.人乳头状瘤病毒HPV-E6及P53蛋白与食管鳞癌关系[J].2000,(5).
[22]沈志祥,曹歌,孙军.结直肠癌组织COX-2 mRNA表达的临床病理意义[J].2001,(9).
[23]HU Liu,YUAN Wang,Qing Zhou,etc.The point mutation of p53 gene exon7 in hepatocellular carcinoma from Anhui Province, a non HCC prevalent area in China[J].2002,(3).
[24]刘海峰,刘为纹,房殿春,等.幽门螺杆菌诱导胃粘膜上皮细胞凋亡和增殖与p53基因表达[J].2001,(11).
[25]王东旭,房殿春,刘为纹.胃粘膜肠化及异型增生和胃癌组织中多基因异常[J].2000,(8).
[26]Liu Liang Qin,Jian Jia Su,YUAN Li,etc.Expression of IGF-Ⅱ, p53, p21 and HBxAg in precancerous events of hepatocarcinogenesis induced by AFB1 and/or HBV in tree shrews[J].2000,(1).
[27]周晓东,于皆平,冉宗学,等.结肠肿瘤cFLIP基因表达与p53突变的关系[J].2002,(5).
[28]刘江伟,李开宗.胰腺癌与癌基因及抑癌基因[J].2001,(1).
[29]陈世耀,王吉耀,纪元,等.幽门螺杆菌与蛋白激酶C在胃癌及癌前病变基因突变中的作用[J].2001,(3).
[30]黄致治,吴贤英,梁英锐,等.食管基底细胞样鳞状细胞癌免疫组化研究[J].2000,(10).
[31]郭洁,沈志祥,谭诗云,等.MDM2、P53与P14ARF在结肠肿瘤中的表达及意义[J].2002,(5).
[32].Effect of Boschniakia Rossica on Expression of Gstp, P53 and P21~(Ras)proteins in Early Stage of Chemical Hepatocarcinogenesis and Its Anti-Inflammatory Activities in Rats[J].2000,(6).
[33]Moran EM.Epidemiological and clinical aspects of nonsteroidal anti-inflammatory drugs and cancer risks.[J].2002,21(2).
[34]Zia'ee AA,Hainaut P,Martel Planche G,etc.Distinct pattern of TP53 mutations in squamous cell carcinoma of the esophagus in Iran.[J].2001,20(50).
[35]Zahner G,Wolf G,Ayoub M,etc.Cyclooxygenase-2 overexpression inhibits platelet-derived growth factor-induced mesangial cell proliferation through induction of the tumor suppressor gene p53 and the cyclin-dependent kinase inhibitors p21waf-1/cip-1 and p27kip-1.[J].2002,277(12).
[36]Mestre JR,Dannenberg AJ,Chung WJ,etc.Inhibition of cyclooxygenase-2 gene expression by p53.[J].1999,274(16).
[37]Kawabe A,Imamura M,Shimada Y,etc.Expression of cyclooxygenase-2 in primary and remnant gastric carcinoma: comparing it with p53 accumulation, Helicobacter pylori infection, and vascular endothelial growth factor expression.[J].2002,80(2).
[38]M A, Molina,M, Sitja-Arnau,M G, Lemoine,etc.Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs.[J].1999,59.
[39]Mirza Asra,McGuirk Marnie,Hockenberry TishN,etc.Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway.[J].2002,21(17).
[40]Xu XC.COX-2 inhibitors in cancer treatment and prevention, a recent development.[J].2002,13(2).
[41]NAOKO LIDA,HIDEAKI ODA,SHIGETOSHI AISO,etc.Infrequent P53 Gene Mutation and Expression of the Cardia Adenocarcinomas from a High-Incidence Area of Southwest China[J].2000,(5).