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bFGF对缺血再灌注后肠道内源性bFGF和TGFβ表达的影响
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- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1009-3079.1999.09.020
- Key Word:
- 成纤维细胞生长因子,碱性;转化生长因子β;肠缺血再灌注损伤
Abstract： @@ 缺血再灌注是严重创伤、烧伤休克救治过程中发生的一个共司的病理过程,其中肠道是缺血性损伤打击的主要器官,其受损后结构与功能恢复的好坏将直接影响多脏器功能障碍综合征(MODS)甚至多器官功能衰竭(MSOF)的发生[1].研究发现.某些生长因子不仅能够促进和加速体表创面的修复,而且也可明显减轻和改善内脏缺血后的损伤程度[2,3],表明生长因子在促进缺血性内脏损伤的修复中起重要作用.我们观察缺血-再灌注损伤后肠道自身碱性成纤维细胞生长因子(bFGF)和转化生长因子β(TGF β)表达的变化规律,以及外源性应用bFGF治疗后对内源性bFGF和TGF β表达量的影响,探讨生长因子促进内脏损伤修复的分子机制及其与器官功能恢复的关系.
- [1]S, Zhi-Yong,Y L, Dong,X H, Wang.Bacterial translocation and multiple system organ failure in bowel ischemia and reperfusion.[J].1992,32(2).
- [2]L, Muthukrishnan,E, Warder,P L, McNeil.Basic fibroblast growth factor is efficiently released from a cytolsolic storage site through plasma membrane disruptions of endothelial cells.[J].1991,148(1).
- [3]Xiaobing Fu,Pedro Cuevas,Guillermo Gimenez-Gallego,etc.Acidic fibroblast growth factor reduces renal morphologic and functional indicators of injury caused by ischemia and reperfusion[J].1996,4(2).
- [4]M B, Sporn,A B, Roberts.Transforming growth factor-beta: recent progress and new challenges.[J].1992,119.
- [5]W D, Thompson,J A, Harvey,M A, Kazmi,etc.Fibrinolysis and angiogenesis in wound healing.[J].1991,165(4).