You Position: Home > Paper
Effect of Hp infection on gastric epithelial cell kinetics in stomach diseases
( views:249, downloads:16 )
- Author:
- No author available
- Journal Title:
- WORLD CHINESE JOURNAL OF DIGESTOLOGY
- Issue:
- 9
- DOI:
- 10.3969/j.issn.1009-3079.1999.09.007
- Key Word:
- 螺杆菌感染;胃疾病;细胞动力学;胃肿瘤
Abstract： 目的观察Hp感染在正常粘膜演变为胃癌过程中对细胞增殖动力学的影响,以探讨Hp的致癌机制.方法研究对象为正常胃粘膜的消化不良患者(NS,n=14)及慢性浅表性胃炎(CSG,n=56)、慢性萎缩性胃炎(CAG,n=20)、慢性萎缩性胃炎伴肠上皮化生(CAGIM,n=16)、不典型增生(Dys,n=18)、胃癌(GC,n=17)Hp阳性与阴性患者.应用Ki-67免疫组化技术评价胃幽门窦上皮细胞增生,并用标记指数百分率(LI%)来表示.结果 Hp阳性患者(n=75)的Ki-67 LI%为17±5,Hp阴性患者(n=52)的Ki-67 LI%为13±6,差异有显著性(P＜0.05);伴有Hp感染的CSG与NS或Hp阴性的CSG患者相比LI%增加(P＜0.01);CAG,CAGIM,Dys,GC的Hp阳性与阴性患者的LI%相比无显著差异;五种胃病无论Hp阳性或阴性患者与正常者相比,LI%明显增加(P＜0.01).LI%与胃粘膜炎症程度无关.结论 Hp感染促进胃上皮细胞过度增殖主要发生在胃粘膜病变的早期,并不影响在癌前病变或胃癌患者中所见到的上皮细胞增生增加.这进一步证明Hp感染可能是胃癌发生过程中的始动步骤.
- [1]L D, Wang,S T, Shi,Q, Zhou,etc.Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis.[J].1994,59.
- [2]N L, Jones,P T, Shannon,E, Cutz,etc.Increase in proliferation and apoptosis of gastric epithelial cells early in the natural history of Helicobacter pylori infection.[J].1997,151.
- [3]R J Cahill,C Kilgallen,S Beattie,etc.Gastric epithelial cell kinetics in the progression from normal mucosa to gastric carcinoma.[J].1996,38(2).
- [4]D A Lynch,N P Mapstone,A M Clarke,etc.Cell proliferation in Helicobacter pylori associated gastritis and the effect of eradication therapy.[J].1995,36(3).
- [5]S\u00f8rbye Halfdan,Kvinnsland Steinar,Svanes Knut.Effect of salt-induced mucosal damage and healing on penetration of N -methyl- N\u2032-nitro- N -nitrosoguanidine to proliferative cells in the gastric mucosa of rats[J].1994.
- [6]The EUROGAST Study Group.An international association between Helicobacter pylori infection and gastric cancer[J].1993,341(8857).