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Clinical Observation of Craniocerebral Injury Application with Naloxone in Early Adequate Treatment
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- Author:
- No author available
- Journal Title:
- AEROSPACE MEDICINE
- Issue:
- 10
- DOI:
- No doi available
- Key Word:
- 纳洛酮;颅脑损伤;β内啡肽
Abstract： 目的:观察早期足量应用纳洛酮治疗颅脑损伤的临床疗效.方法:将纳入的颅脑损伤患者66例以随机数字表法分为实验组(n=33)及对照组(n=33),两组均给予常规治疗,实验组在此基础上加用纳洛酮注射剂体重,用500 ml乳酸钠林格氏液稀释后微量注射泵持续静滴24h,连用7 d后减量为4.8 mg/d,继续应用3 d后停药.两组总疗程均为10 d.比较两组患者入院时及治疗10 d后的格拉斯哥评分(GCS)计分和随访6个月的格拉斯哥预后评分(G0S)计分,以及治疗前后β内啡肽(β-EP)浓度变化.结果:治疗10 d后,两组患者GCS计分与治疗前比较均有显著性差异(P<0.05),且实验组患者治疗10 d后GCS计分与对照组比较差异有统计学意义(P<0.05);治疗后两组患者的β-EP浓度与治疗前相比均明显降低,差异有统计学意义(P<0.05),两组比较差异有统计学意义(P<0.05).6个月后G0S计分两组比较有显著性差异(P<0.05).结论:早期足量使用纳洛酮治疗颅脑损伤可以促进患者清醒和脑功能恢复,保护中枢神经系统.
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