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细胞型朊蛋白的神经保护作用

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Author:: No author available

Journal Title:: JOURNAL OF NAVAL GENERAL HOSPITAL

Issue:: 1

DOI:: 10.3969/j.issn.1009-3427.2007.01.011

Key Word:: 朊蛋白;神经保护;信号传导;氧化应激;细胞凋亡

Abstract：朊蛋白是人类朊蛋白病的致病因子,细胞型朊蛋白是其在细胞内的正常形式,具有神经保护作用.本文综述细胞型朊蛋白的分子生物学特征及其通过细胞表面信号传导、抗氧化应激及抗Bax凋亡所起的神经保护作用,为神经退行性疾病的防治提供新的思路.

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