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The roles of skin-resident memory T cells in dermatoses

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 1

DOI:: 10.3760/cma.j.issn.2096-5540.2019.01.006

Key Word:: No keyword available

Abstract： IntroductionTissue-resident memory T (TRM) cells are a subset of recently identified noncirculating memory T cells characterized by long-term persistence in nonlymphoid peripheral tissues such as the skin,gut,lung,kidney,and reproductive tract[1].The skin is the largest organ in the human body,and estimated 2 × 1010 T cells are present in the entire skin surface.Most of these are CD45RO + memory T cells that express the skin-homing addressins cutaneous leukocyte antigen (CLA) and chemokine receptor (CCR) 4[2].

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