Some signaling pathways associated with ultraviolet radiation-induced skin damage
- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1673-4173.2017.05.014
- Key Word:
- 紫外线;细胞衰老;皮肤肿瘤;信号通路;Ultraviolet rays;Cell aging;Skin neoplasms;Signaling pathway
Abstract： Ultraviolet radiation can cause skin damage,leading to skin photoaging and skin neoplasms.Multiple signaling pathways participate in the occurrence of skin photoaging and (or) skin neoplasms,such as Nrf2-Keap 1-ARE signaling pathway,nuclear factor-κB (NF-κB) signaling pathway,mitogen-activated protein kinase (MAPK) signaling pathway and phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathway.Nrf2 signaling pathway,which is usually activated under oxidative stress,plays an important role in maintaining redox balance and participates in cell metabolism.The activation of NF-κB signaling pathway can up-regulate the level of matrix metalloproteinase (MMP),which is related to skin aging and non-melanoma skin cancers.MAPK signaling pathway participates in the development of skin aging and skin neoplasms.PI3K-Akt-mTOR signaling pathway is mainly related to skin neoplasms.Ultraviolet radiation can induce activation of the above signaling pathways,participate in the occurrence and development of skin aging and skin neoplasms.Further researches on the above signaling pathways may provide new methods for the prevention of and protection from skin photoaging or skin neoplasms.
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