Drug provocation tests in the diagnosis of drug hypersensitivity reactions
- Author:
- No author available
- Journal Title:
- International Journal of Dermatology and Venereology
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-4173.2016.04.009
- Key Word:
- 药用制剂;超敏反应;诊断;方法;药物激发试验;Pharmaceutical preparations;Hypersensitivity;Diagnosis;Methods;Drug provocation tests
Abstract： Drug provocation tests (DPTs) are considered to be not only a gold standard for the diagnosis and exclusion of drug hypersensitivity,but also a safe and efficient approach to seeking alternative medicines.The operation procedures for DPTs have not yet been internationally unified.At present,consensus has been reached that prolonged successive provocation in addition to routine daily oral provocation can improve the positive rate of DPTs.DPTs have a high negative predictive value of more than 90％,and are fairly safe.Almost all positive reactions to DPTs,even long-term DPTs in children,manifest as skin eruptions or urticaria/angioedema,which are mild and easily controlled.Many studies on the diagnostic value,safety and acceptance of SPTs among patients indicate that further researches are required to develop safer and more accurate operation procedures.
- [1]Janni, Hjortlund,Charlotte Gotthard, Mortz,Per Stahl, Skov,etc.One-week oral challenge with penicillin in diagnosis of penicillin allergy.[J].2012,92(3).
- [2]Antonino Romano,Jean-Christoph Caubet.Antibiotic Allergies in Children and Adults: From Clinical Symptoms to Skin Testing Diagnosis[J].2014,2(1).
- [3]Solensky, Roland,Khan, David A..Evaluation of Antibiotic Allergy: the Role of Skin Tests and Drug Challenges[J].2014,14(9/10).
- [4]Chiriac Anca Mirela,Demoly Pascal.Drug provocation tests: up-date and novel approaches[J].2013,9(1).
- [5]W. Aberer,A. Bircher,A. Romano,etc.Drug provocation testing in the diagnosis of drug hypersensitivity reactions: general considerations[J].2003,58(9).
- [6]Zambonino,M.A.,Corzo,J.L.,Mu?oz,C.,etc.Diagnostic evaluation of hypersensitivity reactions to beta-lactam antibiotics in a large population of children[J].2014,25(1).
- [7]Borch JE,Bindslev Jensen C.Full-course drug challenge test in the diagnosis of delayed allergic reactions to penicillin.[J].2011,155(3).
- [8]Ponvert C,Weilenmann C,Wassenberg J,etc.Allergy to betalactam antibiotics in children: a prospective follow-up study in retreated children after negative responses in skin and challenge tests.[J].2007,62(1).
- [9]Francesca Mori,Antonella Cianferoni,Simona Barni,etc.Amoxicillin Allergy in Children: Five-Day Drug Provocation Test in the Diagnosis of Nonimmediate Reactions[J].2015,3(3).
- [10]P. Demoly,A. Romano,C. Botelho,etc.Determining the negative predictive value of provocation tests with beta-lactams[J].2010,65(3).
- [11]Picard,M.,Paradis,L.,Nguyen,M.,etc.Outpatient penicillin use after negative skin testing and drug challenge in a pediatric population[J].2012,33(2).
- [12]Lemaitre B,Gervaix A,Eigenmann PA,etc.The role of penicillin in benign skin rashes in childhood: a prospective study based on drug rechallenge.[J].2011,127(1).
- [13]Misirlioglu, Emine D.,Toyran, Muge,Capanoglu, Murat,etc.Negative predictive value of drug provocation tests in children[J].2014,25(7).
- [14]Kao,L.,Rajan,J.,Roy,L.,etc.Adverse reactions during drug challenges: A single US institution's experience[J].2013,110(2).
- [15]Ponvert C,Perrin Y,Bados Albiero A,etc.Allergy to betalactam antibiotics in children: results of a 20-year study based on clinical history, skin and challenge tests.[J].2011,22(4).
- [16].Drug allergy: an updated practice parameter.[J].2010,105(4).
- [17]Defrance C,Bousquet PJ,Demoly P.Evaluating the negative predictive value of provocation tests with nonsteroidal anti-inflammatory drugs.[J].2011,66(11).
- [18]Waton J,Pouget Jasson C,Loos Ayav C,etc.Drug re-challenges in cutaneous adverse drug reactions: information and effectiveness in the long-term management of patients.[J].2011,66(7).