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Cytokines and immunology of syphilis: an update

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International Journal of Dermatology and Venereology
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Abstract´╝Ü Syphilis is a systemic sexually transmitted disease caused by Treponema pallidum (TP).TP infection may induce a complex immune response in the host,and a variety of cytokines play important roles in the occurrence and development of syphilis.In the early stage of the infection,Th1-type cellular immune responses,which are responsible for the clearance of TP,predominate.With disease progression,Th2-type humoral immune responses,which can result in the escape of TP from immunity,are gradually enhanced.This article describes the roles of 7 kinds of cytokines (including Thl-type,Th2-type,and Thl7-type cytokines) and some chemotactic factors in the pathogenesis of syphilis.

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