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Effects of ultraviolet radiation on DNA methylation

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-4173.2014.04.020

Key Word:: 紫外线;甲基化;细胞衰老;皮肤肿瘤;Ultraviolet rays;Methylation;Cell aging;Skin neoplasms

Abstract： DNA methylation,which refers to a chemical modification process in which a methyl group is covalendy binding to the 5-position of the cytosine ring in CpG dinucleotides to form 5-methylcytosine under the catalysis by DNA methyltransferases (DNMTs),is a key epigenetic modification for gene regulation and mutation.Recent studies have shown that aberrant DNA methylation patterns exist in photoaged skin and ultraviolet radiation-induced skin tumors,which may be caused by decreased expression and activity of DNMT1,base excision repair and nucleotide excision repair,growth arrest,DNA-damage-inducible protein 45 alpha (Gadd45a)-mediated DNA demethylation,and so on.

Reference

[1]Barreto Guillermo,Schäfer Andrea,Marhold Joachim,etc.Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation[J].2007,445(7128).
[2]Grönniger, Elke,Weber, Barbara,Heil, Oliver,etc.Aging and Chronic Sun Exposure Cause Distinct Epigenetic Changes in Human Skin.[J].2010,6(5).
[3]Qing Dai,Shinsuke Ito,Yi Zhang,etc.Tet Proteins Can Convert 5-Methylcytosine to 5-Formylcytosine and 5-Carboxylcytosine[J].2011,333(Sep.2 TN.6047).
[4]Zhu, Xiaohua,Qin, Haihong,Li, Feng,etc.Effects of ultraviolet B exposure on DNA methylation in patients with systemic lupus erythematosus[J].2013,5(4).
[5]Anshu Mittal,Chandrika Piyathilake,Yukihiko Hara,etc.Exceptionally High Protection of Photocarcinogenesis by Topical Application of (-)-Epi gal locatechin-3-Gal late in Hydrophilic Cream in SKH-1 Hairless Mouse Model: Relationship to Inhibition of UVB-Induced Global\{DNA\} Hypomethylation[J].2003,5(6).
[6]Cabrera,Folgueras AR,Fanjul Fernandez M.Matrix metalloproteinases: evolution, gene regulation and functional analysis in mouse models.[J].2010,1803(1).
[7]Skrygan,M.,Sand,M.,Gambichler,T..Loss of 5-hydroxymethylcytosine and ten-eleven translocation 2 protein expression in malignant melanoma[J].2013,23(3).
[8]Zhao S,Li Y,Gao F,etc.Overexpression of the growth arrest and DNA damage-induced 45alpha gene contributes to autoimmunity by promoting DNA demethylation in lupus T cells.[J].2010,62(5).
[9]Seung-Gi Jin,Cai Guo,Pfeifer, Gerd P..GADD45A Does Not Promote DNA Demethylation.[J].2008,4(3).
[10]Omar Abdel-Wahab,Jay P Patel,Alan H Shih,etc.The role of mutations in epigenetic regulators in myeloid malignancies.[J].2012,12(9).
[11]Yang,H.,Liu,Y.,Bai,F.,etc.Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation[J].2013,32(5).
[12]Vaid M,Katiyar SK,Nandakumar V,etc.Aberrant DNA hypermethylation patterns lead to transcriptional silencing of tumor suppressor genes in UVB-exposed skin and UVB-induced skin tumors of mice.[J].2011,32(4).
[13]Rochette PJ,Lacoste S,Therrien JP.Influence of cytosine methylation on ultraviolet-induced cyclobutane pyrimidine dimer formation in genomic DNA.[J].2009,665(1/2).
[14]Sathyanarayana, U. G.,Moore, A. Y.,Li, L.,etc.Sun exposure related methylation in malignant and non-malignant skin lesions[J].2007,245(1).
[15]Li XP,Zhang M,Wang GS.Ultraviolet B exposure of peripheral blood mononuclear cells of patients with systemic lupus erythematosus inhibits DNA methylation.[J].2009,18(12).
[16]Hozefa Bandukwala,Lakshminarayan M. Iyer,Yinghua Shen,etc.Conversion of 5-Methylcytosine to 5-Hydroxymethylcytosine in Mammalian DNA by MLL Partner TET1[J].2009,324(TN.5929).
[17]EVA BALADA,JOSEP ORDI-ROS,MIQUEL VILARDELL-TARRES.DNA Methylation and Systemic Lupus Erythematosus[J].2007,1108(jun).
[18]Schinke C,Sosman J,Greally J,etc.Aberrant DNA methylation in malignant melanoma.[J].2010,20(4).
[19]Jin, Bilian,Robertson, Keith D..DNA Methyltransferases, DNA Damage Repair, and Cancer[J].2013,754.