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Treatment of Mycoplasma genitalium infection and macrolide resistance in Mycoplasma genitalium

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Author:: No author available

Journal Title:: International Journal of Dermatology and Venereology

Issue:: 6

DOI:: 10.3760/cma.j.issn.1673-4173.2012.06.010

Key Word:: 生殖支原体;抗药性;大环内酯类;Mycoplasma genitalium;Drug resistance;Macrolides

Abstract： Mycoplasma genitalium(Mg)is a common cause of nongonococcal urethritis and cervicitis.Macrolide antibiotics,especially azithromycin,have been used as the first-line therapy for patients with Mg infection.Macrolide-resistant Mg strains have been isolated from some patients with Mg-associated and treatment-resistant non-gonococcal urethritis.It has been revealed that macrolide resistance is mainly associated with mutations in the domainⅤ?of 23S rRNA and in ribosomal protein genes L4 and L22.

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