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Annexin A2: structure, function and relevance to associated skin diseases
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-4173.2011.01.008
- Key Word:
- 银屑病;抗磷脂综合征;疤痕;膜联蛋白A2;Psoriasis;Antiphospholipid syndrome;Cicatrix;Annexin A2
Abstract： As a calcium-dependent, phospholipid membrane-binding protein, annexin A2 exists as a monomer, heterodimer or tetramer in skin tissue and many cells.Annexin A2 plays a critical role in various skin diseases, including psoriasis, antiphospholipid syndrome, keloids and scar cancer by promoting DNA synthesis in keratinocytes, interacting with macrophages through Toll-like receptor 4, and affecting plasmin system together with β2-glycoprotein Ⅰ(β2GPI).
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