Role of T lymphocyte-mediated immunity in the pathogenesis and treatment of herpes zoster
- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-4173.2011.01.004
- Key Word:
- T淋巴细胞;免疫,细胞;疱疹,带状;治疗;T-lymphocytes;Immunity,cellular;Herpes zoster;Therapy
Abstract： Herpes zoster is a skin disease caused by the reactivation of latent varicella zoster virus (VZV)in the posterior root ganglia of spinal nerves or sensory ganglia of cranial nerves.It is associated with a decline in VZV-specific cell-mediated immunity.To boost VZV-specific cell-mediated immunity via immunizing with VZV-targeted vaccines may reduce the incidence and severity of herpes zoster in high-risk populations.Once herpes zoster develops, antivirals and appropriate analgesics should be administrated as early as possible to relieve symptoms and prevent the development of post-herpetic neuralgia.Further research into the mechanisms of T lymphocyte-mediated immunity in herpes zoster may provide a solid theoretical basis for the immunotherapy of herpes zoster.
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