Management of keloids
- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 1
- DOI:
- 10.3760/cma.j.issn.1673-4173.2011.01.003
- Key Word:
- 瘢痕疙瘩;综合疗法;Keloid;Combined modality therapy
Abstract： The pathogenesis of keloids remains obscure, and its treatment is troublesome.Comprehensive therapy is usually applied for its management in clinical settings.Surgical removal combined with radiotherapy or intralesional glucocorticoids is the first-line treatment for keloids.Radiotherapy, which includes superficial X ray therapy, electron beam therapy, etc, often has little carcinogenicity.Sillicon gel sheet and pressure therapy usually serve as the basic adjunctive treatment of keloids, which can soften and flatten keloids and improve subjective symptoms and have shown favorable efficacy in all stages of keloids.Effective drugs for keloids mainly include asiaticoside, alpha asiaticoside cream, imiquimod 5% cream, etc.Gene therapy as well as biological preparations may have an inviting prospect for the management of keloids.Satisfactory outcomes may be achieved by combined modality therapy with the above regimens following individual evaluation of eonditions in patients with keloids.
- [1]方方,赵亮,吴信峰,等.手术加综合疗法治疗瘢痕疙瘩的临床观察[J].2006,(4).
- [2]Sela M,Savion Y.Prefabricated pressure earring for earlobe keloids.[J].2008,99(5).
- [3]Berman B,Harrison Balestra C,Perez OA.Treatment of keloid scars post-shave excision with imiquimod 5% cream: A prospective, double-blind, placebo-controlled pilot study.[J].2009,8(5 Suppl.CRITICAL.).
- [4]Yoshida K,Miyashita T,Yoshitatsu S,etc.Is radiation therapy for keloids acceptable? The risk of radiation-induced carcinogenesis.[J].2009,124(4).
- [5]I, Bodokh,P, Brun.[Treatment of keloid with intralesional bleomycin].[J].1996,123(12).
- [6]Dimitroulis D,Chrisostomidis G,Vasilopoulou A,etc.Management of external ear keloids using form-pressure therapy.[J].2008,33(3).
- [7]Xu B,Wang JC,Liu ZZ,etc.Efficacy of recombinant adenovirus-mediated double suicide gene therapy in human keloid fibroblasts.[J].2008,33(3).
- [8]Berman B,Villa A.Imiquimod 5% cream for keloid management.[J].2003,29(10).
- [9]Lewanski C,Lowdell C,Botwood N.The risks of treating keloids with radiotherapy.[J].1999,72(864).
- [10]Adair MA,Foster TD,Gold MH,etc.Prevention of hypertrophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an office setting.[J].2001,27(7).
- [11]Muneuchi G,Ito O,Igawa HH,etc.Long-term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients.[J].2006,40(2).
- [12]B, Berman,H C, Bieley.Adjunct therapies to surgical management of keloids.[J].1996,22(2).
- [13]Mark W. Clemens,Smitha Sonni,Steven P. Davison,etc.Efficacy of Intralesional 5-Fluorouracil and Triamcinolone in the Treatment of Keloids[J].2009,29(1).
- [14]Ragoowansi R,Cornes PG,Moss AL,etc.Treatment of keloids by surgical excision and immediate postoperative single-fraction radiotherapy.[J].2003,111(6).
- [15]Raposo-Do-Amaral CM,Cintra ML,Zarpellon S,etc.Silicone versus nonsilicone gel dressings: a controlled trial.[J].2001,27(8).
- [16]Kelly,A.P..Update on the Management of Keloids[J].2009,28(2).
- [17]Wang QQ,Fang F,Qian G,etc.Giant primary cutis verticis gyrata successfully treated with surgical excision and tissue expansion.[J].2006,32(5).