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Influences of ion channels on skin barrier repair
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4173.2010.02.011
- Key Word:
- 离子通道;皮肤;功能恢复;Ion channels;Skin;Recovery of function
Abstract： The barrier function of epidermis is maintained via continuous renewal and repair. Ion channels can influence the speed of barrier repair via modulating intracellular and extracellular ion concentration of keratinocytes. Related ion channels include voltage-gated calcium channel, voltage-gated magnesium channel, vohage-gated sodium channel, ligand-gated chloride channel, and ligand-gated non-selective cation channel. P2X receptor, TRPV receptor. glutamate receptor and nicotinic acetylcholine receptor all belong to ligand-gated non-selective cation channel. Ion channels affect barrier repair by either direct or indirect mediation of signal transduction via neurotransmitters and G protein-coupled receptors.
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