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Toll-like receptors and immunity
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 2
- DOI:
- 10.3760/cma.j.issn.1673-4173.2008.02.007
- Key Word:
- Toll样受体;免疫,天然;皮肤疾病
Abstract： Toll样受体是迄今认识的第一个通过感知微生物病原体直接作出防御反应的天然免疫识别受体.目前已发现,Toll样受体家族中的TLR 1-11,它们在固有性免疫防御中起重要作用,同时也能调节适应性免疫,是连接天然免疫和适应性免疫的桥梁.Toll样受体将成为治疗痤疮、念珠菌病和尖锐湿疣等感染性疾病的新靶点.
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