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Endothelin Family and Their Receptors in Malignant Melanoma

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 4

DOI:: 10.3760/cma.j.issn.1673-4173.2006.04.017

Key Word:: 内皮素-1;内皮素-3;内皮素受体B;黑色素瘤

Abstract：内皮素受体B作为一种重要的内皮素家族受体,在恶性黑素瘤中与其配体内皮素-1和内皮素-3结合而被激活.目前研究表明,在绝大多数的恶性黑素瘤中内皮素受体B的表达上调并且其激活介导的一系列生物学效应在恶性黑素瘤的发生、发展和转移等过程中起重要的作用,内皮素受体B已被公认为是一种重要的恶性黑素瘤进展标志物.对内皮素受体B介导的信号转导路径下游具体分子机制的深入理解,将为进一步研究恶性黑素瘤的发病机制、治疗带来新的契机和希望.

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