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Hair Follicles Related Signal Transduction
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- Author:
- No author available
- Journal Title:
- INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1673-4173.2006.04.013
- Key Word:
- 毛囊;信号转导;Wnt;TGF-β;TNF;FGFs;hedgehog
Abstract： 信号转导指外界环境因子和胞间通讯信号分子等作用于细胞表面(或胞内)受体后,跨膜传递形成胞内第二信使,以及经过其后的信号途径组分级联传递、引起细胞生理反应和诱导基因表达的过程.毛囊有规律地经历生长期、退行期、休止期变化.出生后毛发生长倚赖毛囊上皮细胞增殖和分化的精确平衡,参与其中的信号通路包括Wnt、转化生长因子-β、肿瘤坏死因子、成纤维细胞生长因子、Hedgehog等.各信号通路存在复杂的交互影响.
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