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Molecular Basis of Herpes Simplex Virus Latent Infection

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Author:: No author available

Journal Title:: INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY

Issue:: 3

DOI:: 10.3760/cma.j.issn.1673-4173.2006.03.022

Key Word:: 单纯疱疹病毒属;潜伏相关转录体;潜伏;组蛋白

Abstract：单纯疱疹病毒在体内的生存策略是建立潜伏感染,一定条件下被激活而致病情复发.虽然近年来在分子水平对潜伏感染和再激活进行了相当的研究,但确切机制尚不十分清楚.目前受到关注的主要有潜伏相关转录体、立即早期基因、病毒蛋白16、组蛋白修饰以及CD8+T细胞.进一步研究有助于寻找和发现针对性预防和治疗HSV感染的新方法或药物.

Reference

[1]Nurith Mador,Efrat Braun,Hillel Haim,etc.Transgenic Mouse with the Herpes Simplex Virus Type 1 Latency-Associated Gene: Expression and Function of the Transgene[J].2003,77(23).
[2]Halford WP,Schaffer PA.ICP0 is required for efficient reactivation of herpes simplex virus type 1 from neuronal latency.[J].2001,75(7).
[3]Pichyangkura R,Fraser NW,Trojanowski JQ,etc.The transcriptional activation domain of VP16 is required for efficient infection and establishment of latency by HSV-1 in the murine peripheral and central nervous systems.[J].1999,259(1).
[4]Pesnicak L,Krause PR,Wang K,etc.The 2.2-kilobase latency-associated transcript of herpes simplex virus type 2 does not modulate viral replication, reactivation, or establishment of latency in transgenic mice.[J].2001,75(17).
[5]Iizuka, M.,Smith, M. M..Functional consequences of histone modifications[J].2003,13(2).
[6]Herrera FJ,Triezenberg SJ.VP16-dependent association of chromatin-modifying coactivators and underrepresentation of histones at immediate-early gene promoters during herpes simplex virus infection.[J].2004,78(18).
[7]Fraser NW,Kent JR,Gardner J,etc.During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription.[J].2004,78(18).
[8]Nash AA.T cells and the regulation of herpes simplex virus latency and reactivation (comment)[J].2000,191(9).
[9]Kubat NJ,Amelio AL,Bloom DC,etc.The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription.[J].2004,78(22).
[10]Kinchington PR,Harvey SAK,Decman V,etc.Gamma interferon can block herpes simplex virus type 1 reactivation from latency, even in the presence of late gene expression[J].2005,79(16).
[11]Hagglund R,Roizman B.Role of ICP0 in the strategy of conquest of the host cell by herpes simplex virus 1 [Review][J].2004,78(5).
[12]Fraser NW,Miller CG,Kent JR,etc.Herpes simplex virus latency-associated transcript gene function.[J].2003,9(3).
[13]Marshall KR,Lachmann RH,Efstathiou S,etc.Long-term transgene expression in mice infected with a herpes simplex virus type 1 mutant severely impaired for immediate-early gene expression.[J].2000,74(2).
[14]Hyun Jin Kwun,Kyung Lib Jang.Transcriptional Regulation of Herpes Simplex Virus Type 1 ICPO Promoter by Virion Protein 16[J].2000,3(1).
[15]Coffin RS,Palmer JA,Groutsi F,etc.Multiple immediate-early gene-deficient herpes simplex virus vectors allowing efficient gene delivery to neurons in culture and widespread gene delivery to the central nervous system in vivo.[J].2001,75(9).
[16]Everett RD.ICP0, a regulator of herpes simplex virus during lytic and latent infection.[J].2000,22(8).
[17]Millhouse S,Wigdahl B.Molecular circuitry regulating herpes simplex virus type 1 latency in neurons.[J].2000,6(1).
[18]Gough G,Coffin RS,Thomas SK,etc.Herpes simplex virus latency-associated transcript encodes a protein which greatly enhances virus growth, can compensate for deficiencies in immediate-early gene expression, and is likely to function during reactivation from virus latency.[J].1999,73(8).
[19]Wysocka J.,Herr W..The herpes simplex virus VP16-induced complex: the makings of a regulatory switch [Review][J].2003,28(6).
[20]Khanna KM,Lepisto AJ,Decman V,etc.Immune control of herpes simplex virus during latency.[J].2004,16(4).
[21]Halford WP,Kemp CD,Isler JA,etc.ICP0, ICP4, or VP16 expressed from adenovirus vectors induces reactivation of latent herpes simplex virus type 1 in primary cultures of latently infected trigeminal ganglion cells.[J].2001,75(13).
[22]Mador N,Panet A,Steiner I.The latency-associated gene of herpes simplex virus type 1 (HSV-1) interferes with superinfection by HSV-1.[J].2002,8(Suppl.2).
[23]Thompson RL.,Sawtell NM..The Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Regulates the Establishment of Latency[J].1997,71(7).
[24]van Lint AL,Kleinert L,Clarke SR,etc.Latent infection with herpes simplex virus is associated with ongoing CD8+ T-cell stimulation by parenchymal cells within sensory ganglia.[J].2005,79(23).
[25]Bonneau RH,Khanna KM,Kinchington PR,etc.Herpes simplex virus-specific memory CD8(+) T cells are selectively activated and retained in latently infected sensory Ganglia.[J].2003,18(5).
[26]Slanina SM,Yukht A,Ghiasi H,etc.The latency-associated transcript gene enhances establishment of herpes simplex virus type 1 latency in rabbits.[J].2000,74(4).
[27]Ghiasi H.,Perng GC.,Nesburn AB.,etc.Either a CD4(+) or CD8(+) T cell function is sufficient for clearance ofinfectious virus from trigeminal ganglia and establishment of herpessimplex virus type 1 latency in mice[J].1999,27(6).